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Lifchem Fine Chemicals Co., Ltd

Lifchem Fine Chemicals Co., Ltd

Biochemicals Assay kits

colorimetric / September 15, 2021

Green fluorescent protein-based lactate and pyruvate indicators suitable for biochemical assays and live cell imaging

Green fluorescent protein-based lactate and pyruvate indicators suitable for biochemical assays and live cell imaging
Glycolysis is the metabolic pathway that converts glucose into pyruvate, whereas fermentation can then produce lactate from pyruvate. Here, we developed single fluorescent protein (FP)-based lactate and pyruvate indicators with low EC50 for hint detection of metabolic molecules and live cell imaging and named them “Green Lindoblum” and “Green Pegassos,” respectively.
Green Lindoblum (EC50 of 30 µM for lactate) and Green Pegassos (EC50 of 70 µM for pyruvate) produced a 5.2- and 3.3-fold change in fluorescence depth in response to lactate and pyruvate, respectively. Green Lindoblum measured lactate ranges in mouse plasma, and Green Pegassos together with D-serine dehydratase efficiently estimated D-serine ranges launched from mouse main cultured neurons and astrocytes by measuring pyruvate degree.
Furthermore, live cell imaging evaluation revealed their utility for dual-colour imaging, and the interaction between lactate, pyruvate, and Ca2+ in human induced pluripotent stem cell-derived cardiomyocytes. Therefore, Green Lindoblum and Green Pegassos might be helpful instruments that detect particular molecules in scientific use and monitor the interaction of metabolites and different associated molecules in various cell varieties.

Promoter Pull-Down Assay: A Biochemical Screen for DNA-Binding Proteins

Transcription components are ubiquitous proteins that affiliate with promoter DNA and regulate gene expression by way of quite a lot of mechanisms. Understanding transcriptional management mechanisms requires in-depth investigation of the binding of transcription components to the promoters they regulate.
There are many in vivo and in vitro strategies for testing the binding of a identified protein to a promoter, reminiscent of chromatin immunoprecipitation and electrophoretic mobility shift assays. However, for these experiments, one will need to have a protein candidate to check and is just not capable of determine unknown proteins sure to a selected promoter.
Thus, the promoter pull-down assay was developed to fill this void. This technique makes use of DNA as bait to seize proteins that bind to a particular promoter, reminiscent of transcription components, from mobile lysates. Coupled with different experiments, the promoter pull-down assay vastly improves the repertoire of strategies obtainable for defining regulatory complexes that affect transcription.

Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay

Inappropriate activation of endosomal TLR7 and TLR8 happens in a number of autoimmune illnesses, particularly systemic lupus erythematosus (SLE). Herein, the event of a TLR8 antagonist competitors assay and its software for hit era of twin TLR7/Eight antagonists are reported.
Green fluorescent protein-based lactate and pyruvate indicators suitable for biochemical assays and live cell imaging
The structure-guided optimization of the pyridone hit <b>3</b> utilizing this biochemical assay together with mobile and TLR8 cocrystal structural information resulted within the identification of a extremely potent and selective TLR7/Eight antagonist (<b>27</b>) with <i>in vivo</i> efficacy.
The two key steps for optimization have been (i) a core morph guided by a TLR7 sequence alignment to attain a twin TLR7/Eight antagonism profile and (ii) introduction of a fluorine within the piperidine ring to scale back its basicity, leading to enticing oral pharmacokinetic (PK) properties and improved TLR8 binding affinity.

Hunting monolignol transporters: membrane proteomics and biochemical transport assays with membrane vesicles of Norway spruce

Monolignol transport throughout lignification is {a partially} solved puzzle: each the mechanism(s) and the transported type of monolignols are unknown in creating xylem of timber. We examined a speculation of an energetic, plasma membrane (PM)-localized transport of monolignol monomers, dimers, and/or glucosidic types with membrane vesicles ready of creating xylem and lignin-forming tissue-cultured cells of Norway spruce (Picea abies L. Karst.), in addition to of management supplies, non-lignifying Norway spruce phloem and tobacco (Nicotiana tabacum L.) BY-2 cells. Xylem and BY-2 vesicles transported each coniferin and p-coumaryl alcohol glucoside, however inhibitor assays prompt this transport being over the tonoplast.
Also membrane vesicles ready from the lignin-forming spruce cells confirmed coniferin transport, however the Km for coniferin was a lot increased than these of xylem and BY-2 cells. Liquid chromatography-mass spectrometry (LC-MS/MS) evaluation of membrane proteins remoted from spruce creating xylem, phloem and lignin-forming cultured cells revealed a number of transporters.
These have been in comparison with a transporter gene set that was gained by a correlation evaluation with a particular set of spruce monolignol biosynthesis genes. Biochemical membrane vesicle assays confirmed no help for the ABC-transporter-mediated monolignol transport however level to secondary energetic transporters (reminiscent of MFS or MATE transporters). In distinction, proteomic and co-expression analyses counsel a job for ABC transporters and MFS transporters.

Protective Mechanism of Acacia saligna Butanol Extract and Its Nano-Formulations in opposition to Ulcerative Colitis in Rats as Revealed by way of Biochemical and Metabolomic Assays

Ulcerative colitis (UC) is a relapsing inflammatory illness of unknown etiology. The elevated danger of most cancers in UC sufferers warrants for the event of novel drug remedies. Herein, this work issues with the investigation of the protecting results of Acacia saligna butanol extract (ASBE) and its nanoformulations on UC in a rat mannequin and its underlying mechanism. Colitis was induced by gradual intrarectal infusion of two mL of 4% (v/v in 0.9% saline) acetic acid. Colon samples have been evaluated macroscopically, microscopically, and assayed for pro-inflammatory cytokine ranges.
To monitor related metabolic adjustments in acetic acid-induced UC mannequin, serum samples have been analyzed for main metabolites utilizing GC-MS adopted by multivariate information analyses. Treatment with ASBE attenuated acetic acid-induced UC as revealed by discount of colon weight, ulcer space, and ulcer index.
ASBE remedy additionally decreased Cyclooxygenase-2 (COX-2), Prostaglandin E2 (PGE2) & Interleukin-1β (IL-1β) ranges within the infected colon. The nano-formulation of ASBE confirmed higher safety than the crude extract in opposition to ulcer indices, elevated PGE2 manufacturing, and histopathological alterations reminiscent of intestinal mucosal lesions and inflammatory infiltration.
Distinct metabolite adjustments have been recorded in colitis rats together with a lower in oleamide and arachidonic acid together with elevated ranges of lactic acid, fructose, and pyroglutamic acid.

Mouse Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit

DLR-bACE1-Mu-48T DL Develop 48T 586.8 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Beta-Site APP Cleaving Enzyme 1 (bACE1) in samples from serum, plasma, tissue homogenates, cerebrospinal fluid or other biological fluids.

Mouse Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit

DLR-bACE1-Mu-96T DL Develop 96T 762 EUR
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Beta-Site APP Cleaving Enzyme 1 (bACE1) in samples from serum, plasma, tissue homogenates, cerebrospinal fluid or other biological fluids.

Human Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit

RDR-bACE1-Hu-48Tests Reddot Biotech 48 Tests 600 EUR

Human Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit

RDR-bACE1-Hu-96Tests Reddot Biotech 96 Tests 830.4 EUR

Mouse Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit

RDR-bACE1-Mu-48Tests Reddot Biotech 48 Tests 613.2 EUR

Mouse Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit

RDR-bACE1-Mu-96Tests Reddot Biotech 96 Tests 850.8 EUR

Rat Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit

RDR-bACE1-Ra-48Tests Reddot Biotech 48 Tests 640.8 EUR

Rat Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit

RDR-bACE1-Ra-96Tests Reddot Biotech 96 Tests 890.4 EUR

Human Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit

RD-bACE1-Hu-48Tests Reddot Biotech 48 Tests 573.6 EUR

Human Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit

RD-bACE1-Hu-96Tests Reddot Biotech 96 Tests 794.4 EUR

Mouse Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit

RD-bACE1-Mu-48Tests Reddot Biotech 48 Tests 586.8 EUR

Mouse Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit

RD-bACE1-Mu-96Tests Reddot Biotech 96 Tests 812.4 EUR

Rat Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit

RD-bACE1-Ra-48Tests Reddot Biotech 48 Tests 613.2 EUR

Rat Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit

RD-bACE1-Ra-96Tests Reddot Biotech 96 Tests 850.8 EUR

Bace1/ Rat Bace1 ELISA Kit

ELI-02505r Lifescience Market 96 Tests 1063.2 EUR

Custom Antibody titration by ELISA up to 2 rabbits and 1 bleed

ELISA-1 Alpha Diagnostics 1 242.4 EUR

BACE1

RA21010 Neuromics 50 ug 522 EUR

Mouse bACE1 ELISA Kit

EMB0322 Abclonal 96Tests 625.2 EUR

Sheep BACE1 ELISA Kit

ESB0322 Abclonal 96Tests 625.2 EUR

Human BACE1 ELISA Kit

EHB0322 Abclonal 96Tests 625.2 EUR

Rat BACE1 ELISA Kit

ERB0322 Abclonal 96Tests 625.2 EUR

Monkey BACE1 ELISA Kit

EMKB0322 Abclonal 96Tests 625.2 EUR

Porcine BACE1 ELISA Kit

EPB0322 Abclonal 96Tests 625.2 EUR

Rabbit BACE1 ELISA Kit

ERTB0322 Abclonal 96Tests 625.2 EUR

Goat BACE1 ELISA Kit

EGTB0322 Abclonal 96Tests 625.2 EUR

Bovine BACE1 ELISA Kit

EBB0322 Abclonal 96Tests 625.2 EUR

Canine BACE1 ELISA Kit

ECB0322 Abclonal 96Tests 625.2 EUR

Chicken BACE1 ELISA Kit

ECKB0322 Abclonal 96Tests 625.2 EUR

Human BACE1 ELISA Kit

ELA-E0718h Lifescience Market 96 Tests 988.8 EUR

BACE1 ELISA KIT|Human

EF006629 Lifescience Market 96 Tests 826.8 EUR

Anserini bACE1 ELISA Kit

EAB0322 Abclonal 96Tests 625.2 EUR

BACE1 Antibody

1-CSB-PA173556 Cusabio
  • 380.40 EUR
  • 292.80 EUR
  • 100ul
  • 50ul
Description: A polyclonal antibody against BACE1. Recognizes BACE1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:15-1:50

BACE1 Antibody

1-CSB-PA002524GA01HU Cusabio
  • 716.40 EUR
  • 399.60 EUR
  • 150ul
  • 50ul
Description: A polyclonal antibody against BACE1. Recognizes BACE1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

BACE1 Antibody

1-CSB-PA002524LA01HU Cusabio
  • 380.40 EUR
  • 402.00 EUR
  • 100ug
  • 50ug
Description: A polyclonal antibody against BACE1. Recognizes BACE1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

BACE1 Antibody

1-CSB-PA150463 Cusabio
  • 380.40 EUR
  • 292.80 EUR
  • 100ul
  • 50ul
Description: A polyclonal antibody against BACE1. Recognizes BACE1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;ELISA:1:2000-1:5000, WB:1:500-1:2000

BACE1 Antibody

1-CSB-PA008418 Cusabio
  • 266.40 EUR
  • 234.00 EUR
  • 100ug
  • 50ug
Description: A polyclonal antibody against BACE1. Recognizes BACE1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/5000

BACE1 Antibody

DF7939 Affbiotech 200ul 420 EUR

BACE1 Antibody

AF6650 Affbiotech 100ul 420 EUR

bACE1 siRNA

20-abx908826 Abbexa
  • 661.20 EUR
  • 878.40 EUR
  • 15 nmol
  • 30 nmol

bACE1 siRNA

20-abx908827 Abbexa
  • 661.20 EUR
  • 878.40 EUR
  • 15 nmol
  • 30 nmol

BACE1 Antibody

6651-100 Biovision 418.8 EUR

BACE1 Antibody

6651-30T Biovision 175.2 EUR

BACE1 antibody

70R-7276 Fitzgerald 50 ug 560.4 EUR
Description: Rabbit polyclonal BACE1 antibody raised against the N terminal of BACE1

Bace1 antibody

70R-8662 Fitzgerald 50 ug 560.4 EUR
Description: Affinity purified rabbit polyclonal Bace1 antibody

BACE1 antibody

70R-15953 Fitzgerald 50 ul 522 EUR
Description: Rabbit polyclonal BACE1 antibody

BACE1 antibody

20R-BR014 Fitzgerald 50 ug 787.2 EUR
Description: Rabbit polyclonal BACE1 antibody

BACE1 antibody

20R-BR015 Fitzgerald 50 ug 787.2 EUR
Description: Rabbit polyclonal BACE1 antibody

BACE1 Antibody

35650-100ul SAB 100ul 302.4 EUR

BACE1 Antibody

ABD7939 Lifescience Market 100 ug 525.6 EUR

BACE1 Antibody

ABD7999 Lifescience Market 100 ug 525.6 EUR

bACE1 siRNA

20-abx900582 Abbexa
  • 661.20 EUR
  • 878.40 EUR
  • 15 nmol
  • 30 nmol

BACE1 protein

E62B011 EnoGene 20ug 411.6 EUR

anti-BACE1

YF-PA17994 Abfrontier 100 ug 483.6 EUR
Description: Rabbit polyclonal to BACE1

BACE1 Antibody

F50757-0.08ML NSJ Bioreagents 0.08 ml 165 EUR

BACE1 Antibody

F50758-0.08ML NSJ Bioreagents 0.08 ml 165 EUR

BACE1 Antibody

F50758-0.4ML NSJ Bioreagents 0.4 ml 379 EUR

BACE1 ELISA Kit (Human) (OKAN05558)

OKAN05558 Aviva Systems Biology 96 Wells 950.4 EUR
Description: Description of target: This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.11 ng/mL

BACE1 ELISA Kit (Mouse) (OKAN05559)

OKAN05559 Aviva Systems Biology 96 Wells 950.4 EUR
Description: Description of target: This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. Homozygous knockout mice for this gene exhibit a wide range of nervous system defects, growth retardation, metabolic abnormalities, and increased neonatal lethality.;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 14.1 pg/mL

BACE1 ELISA Kit (Human) (OKCD06723)

OKCD06723 Aviva Systems Biology 96 Wells 903.6 EUR
Description: Description of target: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein. BACE1, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 0.11ng/mL

BACE1 ELISA Kit (Mouse) (OKCD06724)

OKCD06724 Aviva Systems Biology 96 Wells 934.8 EUR
Description: Description of target: Bace1 is responsible for the proteolytic processing of the amyloid precursor protein (APP). Bace1 cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 12.1pg/mL

BACE1 ELISA Kit (Mouse) (OKEH03206)

OKEH03206 Aviva Systems Biology 96 Wells 794.4 EUR
Description: Description of target: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.39 ng/mL

BACE1 ELISA Kit (Rat) (OKCD02313)

OKCD02313 Aviva Systems Biology 96 Wells 981.6 EUR
Description: Description of target: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. ;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.7 pg/mL

Guinea Pig BACE1 ELISA Kit

EGB0322 Abclonal 96Tests 625.2 EUR

BACE1 Blocking Peptide

DF7939-BP Affbiotech 1mg 234 EUR

BACE1 Conjugated Antibody

C35650 SAB 100ul 476.4 EUR

BACE1 cloning plasmid

CSB-CL002524HU-10ug Cusabio 10ug 637.2 EUR
Description: A cloning plasmid for the BACE1 gene.

anti- BACE1 antibody

FNab00781 FN Test 100µg 658.5 EUR
Description: Antibody raised against BACE1

BACE1 Blocking Peptide

33R-3496 Fitzgerald 100 ug 216 EUR
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of BACE1 antibody, catalog no. 70R-7276

bACE1 (pS498) Antibody

abx148520-100ug Abbexa 100 ug 526.8 EUR

BACE1 Polyclonal Antibody

ABP-PAB-31005 Allele Biotech 50 ug Ask for price

BACE1 Polyclonal Antibody

ABP-PAB-31006 Allele Biotech 50 ug Ask for price

BACE1 Rabbit pAb

A5266-100ul Abclonal 100 ul 369.6 EUR

BACE1 Rabbit pAb

A5266-200ul Abclonal 200 ul 550.8 EUR

BACE1 Rabbit pAb

A5266-20ul Abclonal 20 ul 219.6 EUR

BACE1 Rabbit pAb

A5266-50ul Abclonal 50 ul 267.6 EUR

BACE1 Recombinant Protein

96-050 ProSci 0.1 mg 619.8 EUR
Description: Beta-secretase 1 (BACE1) is also known as beta-site APP cleaving enzyme 1 (beta-site amyloid precursor protein cleaving enzyme 1), memapsin-2 (membrane-associated aspartic protease 2), and aspartyl protease 2 (ASP2), β-Secretase , and is a member of the peptidase A1 protein family, BACE1 is a type I  integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. BACE1 is an aspartic-acid protease important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein contains two active site aspartate residues in its extracellular protein domain and may function as a dimer. This protease is responsible for the proteolytic processing of the amyloid precursor protein (APP). Generation of the 40 or 42 amino acid-long amyloid-β peptides that aggregate in the brain of Alzheimer's patients requires two sequential cleavages of the APP. Extracellular cleavage of APP by BACE creates a soluble extracellular fragment and a cell membrane-bound fragment referred to as C99. The elevation of BACE1 levels can be induced by amyloid plaques surrounding neurons at early stages of pathology before neuron death occurs, and may drive a positive-feedback loop in AD.

BACE1 Recombinant Protein

96-051 ProSci 0.1 mg 556.8 EUR
Description: Beta-secretase 1 (BACE1) is also known as beta-site APP cleaving enzyme 1 (beta-site amyloid precursor protein cleaving enzyme 1), memapsin-2 (membrane-associated aspartic protease 2), and aspartyl protease 2 (ASP2), β-Secretase , and is a member of the peptidase A1 protein family, BACE1 is a type I  integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. BACE1 is an aspartic-acid protease important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein contains two active site aspartate residues in its extracellular protein domain and may function as a dimer. This protease is responsible for the proteolytic processing of the amyloid precursor protein (APP). Generation of the 40 or 42 amino acid-long amyloid-β peptides that aggregate in the brain of Alzheimer's patients requires two sequential cleavages of the APP. Extracellular cleavage of APP by BACE creates a soluble extracellular fragment and a cell membrane-bound fragment referred to as C99. The elevation of BACE1 levels can be induced by amyloid plaques surrounding neurons at early stages of pathology before neuron death occurs, and may drive a positive-feedback loop in AD.

BACE1 Recombinant Protein

96-052 ProSci 0.2 mg 556.8 EUR
Description: Beta-secretase 1 (BACE1) is also known as beta-site APP cleaving enzyme 1 (beta-site amyloid precursor protein cleaving enzyme 1), memapsin-2 (membrane-associated aspartic protease 2), and aspartyl protease 2 (ASP2), β-Secretase , and is a member of the peptidase A1 protein family, BACE1 is a type I  integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. BACE1 is an aspartic-acid protease important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein contains two active site aspartate residues in its extracellular protein domain and may function as a dimer. This protease is responsible for the proteolytic processing of the amyloid precursor protein (APP). Generation of the 40 or 42 amino acid-long amyloid-β peptides that aggregate in the brain of Alzheimer's patients requires two sequential cleavages of the APP. Extracellular cleavage of APP by BACE creates a soluble extracellular fragment and a cell membrane-bound fragment referred to as C99. The elevation of BACE1 levels can be induced by amyloid plaques surrounding neurons at early stages of pathology before neuron death occurs, and may drive a positive-feedback loop in AD.

Polyclonal BACE1 Antibody

APG03188G Leading Biology 0.1mg 580.8 EUR
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BACE1 . This antibody is tested and proven to work in the following applications:

Recombinant Human BACE1

P0562 FN Test 100ug 626.83 EUR
Description: Recombinant Human protein for BACE1

BACE1-IN-1

HY-100182 MedChemExpress 5mg 2958 EUR

Anti-BACE1 antibody

PAab00781 Lifescience Market 100 ug 463.2 EUR

Anti-BACE1 antibody

STJ29911 St John's Laboratory 100 µl 332.4 EUR
Description: This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients.

Anti-BACE1 Antibody

STJ193186 St John's Laboratory 200 µl 236.4 EUR

Basic Cytotoxicity Test Kits

CT17001 Neuromics 125 Tests 490.8 EUR

Basic Cytotoxicity Test Kits

CT17002 Neuromics 250 Tests 780 EUR

Total Cytotoxicity Test Kits

CT17003 Neuromics 125 Tests 615.6 EUR

Total Cytotoxicity Test Kits

CT17004 Neuromics 250 Tests 975.6 EUR

Necrosis vs Apoptosis Kits

KF17371 Neuromics 50-100 Tests 522 EUR

Necrosis vs Apoptosis Kits

KF17372 Neuromics 100-200 Tests 921.6 EUR

Pipette Stand Starter Kits

P7700-S1 Benchmark Scientific 1 PC 609.4 EUR

Pipette Stand Starter Kits

P7700-S2 Benchmark Scientific 1 PC 631.32 EUR

T&A Cloning Kits

FYC001-20P Yeastern Biotech 1 vial Ask for price

Sealed Vials Calibration Kits

2659505 Scientific Laboratory Supplies EACH 814.6 EUR

Carcass Sponge Sampling Kits

SWA1038 Scientific Laboratory Supplies PK95 332.88 EUR

BACE1 Antibody, HRP conjugated

1-CSB-PA002524LB01HU Cusabio
  • 380.40 EUR
  • 402.00 EUR
  • 100ug
  • 50ug
Description: A polyclonal antibody against BACE1. Recognizes BACE1 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

BACE1 Antibody, FITC conjugated

1-CSB-PA002524LC01HU Cusabio
  • 380.40 EUR
  • 402.00 EUR
  • 100ug
  • 50ug
Description: A polyclonal antibody against BACE1. Recognizes BACE1 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

BACE1 Antibody, Biotin conjugated

1-CSB-PA002524LD01HU Cusabio
  • 380.40 EUR
  • 402.00 EUR
  • 100ug
  • 50ug
Description: A polyclonal antibody against BACE1. Recognizes BACE1 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Rat BACE1 shRNA Plasmid

20-abx985469 Abbexa
  • 961.20 EUR
  • 1345.20 EUR
  • 150 µg
  • 300 µg

Phospho-BACE1 (Thr252) Antibody

AF3650 Affbiotech 100ul 540 EUR

Human BACE1 shRNA Plasmid

20-abx958402 Abbexa
  • 961.20 EUR
  • 1345.20 EUR
  • 150 µg
  • 300 µg

Mouse BACE1 shRNA Plasmid

20-abx973511 Abbexa
  • 961.20 EUR
  • 1345.20 EUR
  • 150 µg
  • 300 µg

BACE1 recombinant monoclonal antibody

A5095 Bimake 100ul X 3 714 EUR
Description: A recombinant monoclonal antibody from rabbit against human BACE1 for WB,ELISA

BACE1 Recombinant Protein (Human)

RP002572 ABM 100 ug Ask for price

BACE1 Recombinant Protein (Mouse)

RP118622 ABM 100 ug Ask for price

BACE1 Recombinant Protein (Mouse)

RP118625 ABM 100 ug Ask for price

BACE1 Recombinant Protein (Rat)

RP191804 ABM 100 ug Ask for price

MitoPT™ TMRE & TMRM Kits

KF17358 Neuromics 500 Test 574.8 EUR

MitoPT™ TMRE & TMRM Kits

KF17359 Neuromics 500 Test 574.8 EUR

HISTAR DETECTION SYSTEM Kits (OKSA11259)

OKSA11259 Aviva Systems Biology 50 Tests 678 EUR
Description: Description of target: HISTAR DETECTION SYSTEM;Species reactivity: ;Application: IHC-AFF, IHC-FFPE;Assay info: ;Sensitivity:

HISTAR DETECTION SYSTEM Kits (OKSA11260)

OKSA11260 Aviva Systems Biology 150 Tests 1602 EUR
Description: Description of target: HISTAR DETECTION SYSTEM;Species reactivity: ;Application: IHC-AFF, IHC-FFPE;Assay info: ;Sensitivity:

HISTAR DETECTION SYSTEM Kits (OKSA11261)

OKSA11261 Aviva Systems Biology 500 Tests 2422.8 EUR
Description: Description of target: HISTAR DETECTION SYSTEM;Species reactivity: ;Application: IHC-AFF, IHC-FFPE;Assay info: ;Sensitivity:

Rat Neural Stem Cell Kits

PC37123 Neuromics 1 X 10(6) *minimum order 6 vials* 1148.4 EUR

Rat Bace1/ Beta-secretase 1 ELISA Kit

E0115Ra Sunlong 1 Kit 685.2 EUR

Mouse Bace1/ Beta-secretase 1 ELISA Kit

E0159Mo Sunlong 1 Kit 685.2 EUR

Human BACE1/ Beta-secretase 1 ELISA Kit

E0249Hu Sunlong 1 Kit 685.2 EUR

Mouse Bace1(Beta-secretase 1) ELISA Kit

EM0448 FN Test 96T 628.92 EUR
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.094 ng/ml

BACE1 ELISA Kit (Human) : 96 Wells (OKEH00554)

OKEH00554 Aviva Systems Biology 96 Wells 794.4 EUR
Description: Description of target: This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015];Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.31 ng/mL

Mouse Beta- secretase 1, Bace1 ELISA KIT

ELI-02502m Lifescience Market 96 Tests 1038 EUR

Human Beta- secretase 1, BACE1 ELISA KIT

ELI-02503h Lifescience Market 96 Tests 988.8 EUR

Bovine Beta- secretase 1, BACE1 ELISA KIT

ELI-02504b Lifescience Market 96 Tests 1113.6 EUR

Nori® Porcine 3-Plex ELISA Kits-Interferons

GR224009 Genorise Scientific 96-well 603.6 EUR

Nori® Porcine 4-Plex ELISA Kits-Immunoglobulins

GR224017 Genorise Scientific 96-well 654 EUR

Nori® Porcine 6-Plex ELISA Kits-BMP

GR224025 Genorise Scientific 96-well 754.8 EUR

Nori® Porcine 6-Plex ELISA Kits-CCL

GR224026 Genorise Scientific 96-well 754.8 EUR

Nori® Porcine 6-Plex ELISA Kits-MMP

GR224027 Genorise Scientific 96-well 754.8 EUR

Nori® Porcine 6-Plex ELISA Kits-TLR

GR224028 Genorise Scientific 96-well 754.8 EUR

Nori® Porcine 6-Plex ELISA Kits-Hormones

GR224029 Genorise Scientific 96-well 754.8 EUR

Nori® Porcine 6-Plex ELISA Kits-SAA

GR224030 Genorise Scientific 96-well 754.8 EUR

Nori® Porcine 6-Plex ELISA Kits-S100

GR224031 Genorise Scientific 96-well 754.8 EUR

Nori® Porcine 6-Plex ELISA Kits-CXCL

GR224032 Genorise Scientific 96-well 754.8 EUR

Nori® Equine 3-Plex ELISA Kits-Interferons

GR225009 Genorise Scientific 96-well 603.6 EUR

Nori® Equine 4-Plex ELISA Kits-Immunoglobulins

GR225017 Genorise Scientific 96-well 654 EUR

Nori® Equine 6-Plex ELISA Kits-BMP

GR225025 Genorise Scientific 96-well 754.8 EUR

Nori® Equine 6-Plex ELISA Kits-CCL

GR225026 Genorise Scientific 96-well 754.8 EUR

Nori® Equine 6-Plex ELISA Kits-MMP

GR225027 Genorise Scientific 96-well 754.8 EUR

Nori® Equine 6-Plex ELISA Kits-TLR

GR225028 Genorise Scientific 96-well 754.8 EUR

Nori® Equine 6-Plex ELISA Kits-Hormones

GR225029 Genorise Scientific 96-well 754.8 EUR

Nori® Equine 6-Plex ELISA Kits-SAA

GR225030 Genorise Scientific 96-well 754.8 EUR

Nori® Equine 6-Plex ELISA Kits-S100

GR225031 Genorise Scientific 96-well 754.8 EUR

Nori® Equine 6-Plex ELISA Kits-CXCL

GR225032 Genorise Scientific 96-well 754.8 EUR

Nori® Canine 3-Plex ELISA Kits-Interferons

GR226009 Genorise Scientific 96-well 603.6 EUR

Nori® Canine 4-Plex ELISA Kits-Immunoglobulins

GR226017 Genorise Scientific 96-well 654 EUR

Nori® Canine 6-Plex ELISA Kits-BMP

GR226025 Genorise Scientific 96-well 754.8 EUR

Nori® Canine 6-Plex ELISA Kits-CCL

GR226026 Genorise Scientific 96-well 754.8 EUR

Nori® Canine 6-Plex ELISA Kits-MMP

GR226027 Genorise Scientific 96-well 754.8 EUR

Nori® Canine 6-Plex ELISA Kits-TLR

GR226028 Genorise Scientific 96-well 754.8 EUR

Nori® Canine 6-Plex ELISA Kits-Hormones

GR226029 Genorise Scientific 96-well 754.8 EUR

Nori® Canine 6-Plex ELISA Kits-SAA

GR226030 Genorise Scientific 96-well 754.8 EUR

Nori® Canine 6-Plex ELISA Kits-S100

GR226031 Genorise Scientific 96-well 754.8 EUR

Nori® Canine 6-Plex ELISA Kits-CXCL

GR226032 Genorise Scientific 96-well 754.8 EUR

Nori® Bovine 3-Plex ELISA Kits-Interferons

GR228009 Genorise Scientific 96-well 603.6 EUR

Nori® Bovine 4-Plex ELISA Kits-Immunoglobulins

GR228017 Genorise Scientific 96-well 654 EUR

Nori® Bovine 6-Plex ELISA Kits-BMP

GR228025 Genorise Scientific 96-well 754.8 EUR

Nori® Bovine 6-Plex ELISA Kits-CCL

GR228026 Genorise Scientific 96-well 754.8 EUR

Nori® Bovine 6-Plex ELISA Kits-MMP

GR228027 Genorise Scientific 96-well 754.8 EUR

Nori® Bovine 6-Plex ELISA Kits-TLR

GR228028 Genorise Scientific 96-well 754.8 EUR

Nori® Bovine 6-Plex ELISA Kits-Hormones

GR228029 Genorise Scientific 96-well 754.8 EUR

Nori® Bovine 6-Plex ELISA Kits-SAA

GR228030 Genorise Scientific 96-well 754.8 EUR
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Treatment with nano extract restored metabolite ranges to regular and means that cytokine ranges have been regulated by nano extract in UC. Conclusion: ASBE nano extract mitigated in opposition to acetic acid-induced colitis in rats, and the underlying mechanism might be attributed to the modulatory results of ASBE on the inflammatory cascades. The applicability of metabolomics developed on this rat mannequin appears to be essential for evaluating the anti-inflammatory mechanisms of latest therapeutics for acute colitis.
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