Description: WNV Core Antibody: West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins which play a major role for WNV entry into target cells. The viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway as delivery of core gene delivery into the striatum of mouse brain and skeletal muscle resulted in cell death and inflammation.

Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human WNV Core . This antibody is tested and proven to work in the following applications:

Description: WNV, native virus.

Description: Recombinant West Nile Envelope Virus

Description: WNV, native antigen, strain B956 (Uganda), β-Propiolactone and detergent treated; no cytopathic effects detectable after 7 days.

Description: Recombinant West Nile Pre-M Virus

Description: (NT) WNV Core peptide

Description: WNV, native antigen, Strain 385-99 (New York), β-Propiolactone and detergent treated; no cytopathic effects detectable after 7 days.

Description: WNV Active E Antigen, recombinant protein from E. coli.

Description: WNV PreM, recombinant protein from E. coli.

Description: WNV WnvNS3 Protease, recombinant protein from E. coli.

Description: WNV Envelope protein [His], recombinant protein from E. coli.

Description: WNV PreM [His], recombinant protein from E. coli.

Description: Synthetic WNV E protein peptide.

Description: Synthetic WNV preM blocking peptide.

Description: Synthetic WNV E protein blocking peptide.

Description: Synthetic WNV M protein blocking peptide.

Description: WNV Nonstructural Protein 1 [His], recombinant protein from HEK 293 cells.

Description: WNV PreM (aa 124-259), recombinant protein from E. coli.

Description: West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins. However, when the viruses are inside of infected cells, the matrix protein exists in its "pre-M" form as a heterodimer with the envelope proteins. Cleavage of the "pre-M” protein to its mature form occurs during release of the virus; this cleavage leads to the dissociation of the heterodimers. The viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway as delivery of core gene delivery into the striatum of mouse brain and skeletal muscle resulted in cell death and inflammation. The highly glycosylated envelope protein was shown to play a major role for WNV entry into target cells as WNV entry was inhibited by using a recombinant domain III from the envelope glycoprotein. The WNV receptor has recently been identified as alpha v beta 3 integrin.;;For images please see PDF data sheet

Description: WNV E Antigen (aa 590-696) [His], recombinant protein from HEK 293 cells.

Description: WNV E Antigen (aa 291-696) (Ectodomain) [His], recombinant protein from HEK 293 cells.

Description: WNV Nonstructural Protein 1 (aa 782-1102) [His], recombinant protein from E. coli.

Description: Quantitative sandwich ELISA for measuring Human West Nile virus IgG (WNV IgG)  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Human West Nile virus IgG (WNV IgG)  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Human West Nile virus IgG (WNV IgG)  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Human West Nile virus IgM (WNV IgM)  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Human West Nile virus IgM (WNV IgM)  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Human West Nile virus IgM (WNV IgM)  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.