Systematic Review and Meta-Analysis of Randomized Controlled Trials of Liangxue Tongyu Formula on Patients With Acute Intracerebral Hemorrhage.
As a standard Chinese medication (TCM) prescription for acute stroke, Liangxue Tongyu method (LXTYF) was broadly used as auxiliary therapy measure in some scientific apply.
This research aimed to guage the scientific efficacy and security of LXTYF mixed western standard medication (WCM) with WCM just for acute intracerebral hemorrhage (ICH).We systematically searched PubMed, Embase, Cochrane Library, CMB (Chinese biomedicine database), CNKI (China National Knowledge Infrastructure), WanFang, and VIP till August 2019 to substantiate related randomized managed trials (RCTs) in contrast the mix of LXTYF and WCM with WCM alone for the therapy of acute ICH.
Two investigators independently assessed the chance of bias, and extracted and analyzed the information from the recognized research utilizing RevMan 5.3.Zero software program following Cochrane’s commonplace and PRISMA tips. The natural compositions of LXTYF had been additionally assessed.
Results15 RCTs had been recognized, completely recruiting 1648 sufferers with acute intracerebral hemorrhage.
Compared with the WCM alone, the mix remedy of LXTYF with WCM may enhance the scientific efficient charge (RR, 1.21; 95% CI, 1.15-1.25, P < 0.05) and ADL rating (MD, 18.09; 95% CI, 12.11-24.07; P < 0.05), and scale back syndrome scores of the TCM (MD, -4.11; 95% CI, -4.69 to -3.53; P < 0.05) and the Glasgow consequence rating(GOS) (MD=0.43, 95%CI: 0.06 to 0.79, P=0.02) Moreover, there was no ample proof to point the hostile results would enhance in contrast with WCM alone.Based on present proof, we concluded that the mixed remedy had some advantages in treating acute intracerebral hemorrhage.
However, contemplating the potential biases and limitations of our research, further giant, high-quality RCTs are required sooner or later to substantiate or refute the consequences of LFTYF mixed with WCM in acute stroke.
Progress in nanorobotics for advancing biomedicine.
Nanorobotics, which has lengthy been a fantasy within the realm of science fiction, is now a actuality as a result of appreciable developments in numerous fields together with chemistry, supplies, physics, data and nanotechnology up to now many years.
Not solely totally different prototypes of nanorobots whose sizes are nanoscale are invented for numerous biomedical purposes, but in addition robotic nanomanipulators that are capable of deal with nano-objects get hold of substantial achievements for purposes in biomedicine.
The excellent achievements in nanorobotics have considerably expanded the sphere of medical robotics and yielded novel insights into the underlying mechanisms guiding life actions, remarkably displaying an rising and promising method for advancing the analysis & therapy degree within the coming period of customized precision medication.
In this evaluation, the latest advances in nanorobotics (nanorobots, nanorobotic manipulations) for biomedical purposes are summarized from a number of aspects (together with molecular machines, nanomotors, DNA nanorobotics, and robotic nanomanipulators), and the long run views are additionally introduced.