Description: A polyclonal antibody for detection of Noggin from Human, Mouse, Rat. This Noggin antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human Noggin protein at amino acid sequence of 21-70

Description: A polyclonal antibody for detection of Noggin from Human, Mouse, Rat. This Noggin antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human Noggin protein at amino acid sequence of 21-70

Description: A polyclonal antibody for detection of Noggin from Human, Mouse, Rat. This Noggin antibody is for IHC-P, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human Noggin protein at amino acid sequence of 21-70

Description: A Rabbit polyclonal antibody against Dog Noggin (NOG)

Description: A Rabbit polyclonal antibody against Chicken Noggin (NOG)

Description: A Rabbit polyclonal antibody against Human Noggin (NOG)

Description: A Rabbit polyclonal antibody against Mouse Noggin (NOG)

Description: A Rabbit polyclonal antibody against Pig Noggin (NOG)

Description: A Rabbit polyclonal antibody against Rat Noggin (NOG)

Description: A Rabbit polyclonal antibody against Rat Noggin (NOG)

Description: Rabbit polyclonal Noggin antibody raised against the middle region of NOG

Description: Affinity purified Rabbit polyclonal Noggin antibody

Description: Rabbit polyclonal Noggin antibody

Description: Rabbit polyclonal Noggin antibody

Description: Rabbit polyclonal Noggin antibody

Description: A Rabbit polyclonal antibody against Dog Noggin (NOG). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Dog Noggin (NOG). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Dog Noggin (NOG). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Dog Noggin (NOG). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Dog Noggin (NOG). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Dog Noggin (NOG). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Chicken Noggin (NOG). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Chicken Noggin (NOG). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Chicken Noggin (NOG). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Chicken Noggin (NOG). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Chicken Noggin (NOG). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Chicken Noggin (NOG). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Human Noggin (NOG). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Human Noggin (NOG). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Human Noggin (NOG). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Human Noggin (NOG). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Human Noggin (NOG). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Human Noggin (NOG). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Mouse Noggin (NOG). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Mouse Noggin (NOG). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Mouse Noggin (NOG). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Mouse Noggin (NOG). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Mouse Noggin (NOG). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Mouse Noggin (NOG). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Pig Noggin (NOG). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Pig Noggin (NOG). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Pig Noggin (NOG). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Pig Noggin (NOG). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Pig Noggin (NOG). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Pig Noggin (NOG). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Rat Noggin (NOG). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Rat Noggin (NOG). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Rat Noggin (NOG). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Rat Noggin (NOG). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Rat Noggin (NOG). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Rat Noggin (NOG). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Rat Noggin (NOG). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Rat Noggin (NOG). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Rat Noggin (NOG). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Rat Noggin (NOG). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Rat Noggin (NOG). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Rat Noggin (NOG). This antibody is labeled with PE.

Description: Antibody raised against Noggin

Description: A Monoclonal antibody against Human Noggin. The antibodies are raised in Mouse. This antibody is applicable in WB, ICC

Description: Rabbit polyclonal to Noggin.

Description: Mouse monoclonal to Noggin.

Description: A Rabbit polyclonal antibody against Dog Noggin (NOG). This antibody is labeled with APC-Cy7.

Description: A Rabbit polyclonal antibody against Chicken Noggin (NOG). This antibody is labeled with APC-Cy7.

Description: A Rabbit polyclonal antibody against Human Noggin (NOG). This antibody is labeled with APC-Cy7.

Description: A Rabbit polyclonal antibody against Mouse Noggin (NOG). This antibody is labeled with APC-Cy7.

Description: A Rabbit polyclonal antibody against Pig Noggin (NOG). This antibody is labeled with APC-Cy7.

Description: A Rabbit polyclonal antibody against Rat Noggin (NOG). This antibody is labeled with APC-Cy7.

Description: A Rabbit polyclonal antibody against Rat Noggin (NOG). This antibody is labeled with APC-Cy7.

Description: Purified recombinant Human Noggin protein

Description: Purified recombinant Human Noggin protein

Description: Purified recombinant Human Noggin protein

Description: Rabbit polyclonal to Noggin

Description: Mouse polyclonal to Noggin

Description: Rabbit polyclonal to Noggin

Description: Rabbit polyclonal to Noggin

Description: Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant human Noggin is a 46 kDa disulfide-linked homodimer (120-10C) consisting of two 206 amino acid polypeptide chains. Monomeric glycosylated Noggin migrates at an apparent molecular weight of approximately 28.0-33.0 kDa by SDS PAGE analysis under reducing conditions.

Description: Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant human Noggin is a 46 kDa disulfide-linked homodimer (120-10C) consisting of two 206 amino acid polypeptide chains. Monomeric glycosylated Noggin migrates at an apparent molecular weight of approximately 28.0-33.0 kDa by SDS PAGE analysis under reducing conditions.

Description: Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant murine Noggin is a 46.4 kDa disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains.

Description: Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant murine Noggin is a 46.4 kDa disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains.

Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NOG antibody, catalog no. 70R-4585

Description: Purified recombinant Mouse Noggin protein

Description: Noggin is also known as NOG，SYM1, SYNS1 and is a secreted homodimeric glycoprotein whose scaffold contains a cystine-knot topology similar to that of BMPs.Secreted Noggin probably remains close to the cell surface due to its binding of heparincontaining proteoglycans.Noggin inhibits TGF-β signal transduction by binding to TGF-β family ligands and preventing them from binding to their corresponding receptors. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion. During embryogenesis, Noggin antagonizes specific BMPs at defined times, for example, during neural tube, somite and cardiomyocyte growth and patterning. During skeletal development, Noggin prevents chondrocyte hyperplasia, thus allowing proper formation of joints. During culture of human embryonic stem cells (hESC) or neural stem cells under certain conditions, addition of Noggin to antagonize BMP activity may allow stem cells to proliferate while maintaining their undifferentiated state, or alternatively, to differentiate into dopaminergic neurons Noggin also appears to maintain adult stem cell populations in vivo, for example, maintaining neural stem cells within the hippocampus.

Description: Recombinant Human Noggin expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Description: Recombinant Rat Noggin expressed in: E.coli

Description: Recombinant Rat Noggin expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Description: Recombinant Dog Noggin expressed in: E.coli

Description: Recombinant Chicken Noggin expressed in: E.coli

Description: Recombinant Human Noggin expressed in: E.coli

Description: Recombinant Mouse Noggin expressed in: E.coli

Description: Recombinant Pig Noggin expressed in: E.coli

Description: Recombinant Rat Noggin expressed in: E.coli

Description: Recombinant Rat Noggin expressed in: E.coli

Description: Mouse monoclonal to Noggin

Description: Mouse monoclonal to Noggin

Description: Mouse monoclonal to Noggin

Description: Mouse monoclonal to Noggin

Description: Mouse monoclonal to Noggin

Description: A Mouse monoclonal antibody against Human, Rat Noggin (NOG)

Description: A Mouse monoclonal antibody against Human, Rat Noggin (NOG)

Description: A Mouse monoclonal antibody against Human, Rat Noggin (NOG)

Description: Noggin Human Recombinant produced in E.Coli is a non-glycosylated, non-disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains, having a total molecular mass of approximately 46.2 kDa (each chain 23.1 kDa).;Noggin is purified by proprietary chromatographic techniques.

Description: Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant human Noggin is a 46 kDa disulfide-linked homodimer (120-10C) consisting of two 206 amino acid polypeptide chains. Monomeric glycosylated Noggin migrates at an apparent molecular weight of approximately 28.0-33.0 kDa by SDS PAGE analysis under reducing conditions.

Description: Noggin Mouse Recombinant produced in E.Coli is a non-glycosylated, disulfide-linked protein consisting of two 206 amino acid polypeptide chains, having a total molecular mass of approximately 46.4 kDa (each chain 23.2 kDa).

Description: Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant murine Noggin is a 46.4 kDa disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains.

Description: A Mouse monoclonal antibody against Human, Rat Noggin (NOG). This antibody is labeled with APC.

Description: A Mouse monoclonal antibody against Human, Rat Noggin (NOG). This antibody is labeled with Biotin.

Description: A Mouse monoclonal antibody against Human, Rat Noggin (NOG). This antibody is labeled with Cy3.

Description: A Mouse monoclonal antibody against Human, Rat Noggin (NOG). This antibody is labeled with FITC.

Description: A Mouse monoclonal antibody against Human, Rat Noggin (NOG). This antibody is labeled with HRP.

Description: A Mouse monoclonal antibody against Human, Rat Noggin (NOG). This antibody is labeled with PE.