Description: MECA-79 recognizes a carbohydrate epitope shared with a group of sulfation decorated sialomucins, including sulfated ligands for CD62L (CD34, GlyCAM-1, Sgp200, and a subset of MAdCAM-1). This set antigens has been referred to as peripheral node addressin (PNAd) with the molecular mass 50-250 kD. It has been identified that GlcNAc-6-SO4 sulfation contributes to MECA-79 binding and the core 1 beta1,3-N-acetylglucosaminyltransferase is required for the generation of the MECA-79 epitope. MECA-79 is expressed on high endothelial venules (HEV) of lymphoid tissues, chronic inflamed tissues and rheumatoid synovia. The interaction of PNAd with CD62L receptor is involved in tethering and rolling of lymphocytes along HEV in lymphoid tissues. MECA-79 antibody reacts with Mouse, human and many other species PNAd and blocks L-selectin-dependent lymphocyte adhesion in vitro and in vivo.

Description: Lymph Node tissue lysate was prepared by homogenization in lysis buffer (10 mM HEPES pH7.9, 1.5 mM MgCl₂, 10 mM KCl, 1 mM ethylenediaminetetraacetic acid, 10% glycerol, 1% NP-40, and a cocktail of protease inhibitors). Tissue and cell debris was removed by centrifugation. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT.

Description: Lymph node tissue array, 24 cases/48 cores, replacing LY481

Description: Human lymph node tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human lymph node tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated lymph node tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated lymph node tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Description: Normal lymph node tissue array, 30 cases/ 60 cores,

Description: Human Lymph Node Tissue Lysate

Description: Human lymph node tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human lymph node tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the lymph node tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The lymph node tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Description: Lymph node and tonsil tissue array, 12 cases/24 cores, replacing LY241g

Description: Lymph node and tonsil tissue array, 12 cases/24 cores (core size 1.5mm), replacing LY241h

Description: Lymphoma with lymph node tissue array, 12 cases/24 cores, replaced by T203d

Description: Lymphoma with lymph node tissue array, 12 cases/ 24 cores, replacing T203c

Description: Multiple organ lymph node tissue array, 80 cases/80 cores, replacing LN802

Description: Human Lymph Node Lysate Membrane Fraction

Description: Lymphoma and normal lymph node tissue array, 24 cases/72 cores

Description: Innovative Grade US Origin Bovine Lymph Node

Description: Innovative Grade US Origin Bovine Lymph Node

Description: Innovative Grade US Origin Bovine Lymph Node

Description: Innovative Grade US Origin Bovine Lymph Node

Description: Innovative Grade US Origin Porcine Lymph Node

Description: Innovative Grade US Origin Porcine Lymph Node

Description: Innovative Grade US Origin Porcine Lymph Node

Description: Innovative Grade US Origin Porcine Lymph Node

Description: Human Liver Cirrhosis Lymph Node Tissue Lysate

Description: Multiple organ lymphoma and lymph node tissue array,including anaplastic large cell lymphoma (ALCL),diffuse B cell lymphoma,diffuse large B cell lymphoma (DLBCL), diffuse T cell lymphoma,follicular lymphoma, hodgkin's lymphoma, lymphoplasma cell lymphoma,small B lymphocytic lymphoma,small lymphocytic lymphoma (SLL), T-cell lymphoma and normal tissue, 69 cases/207 cores (core size 1.0mm), replacing LM208

Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Description: Lymph node metastatic squamous cell carcinoma tissue array, 80 cases/80 cores

Description: Lung cancer and matched lymph node metastasis tissue array, including pathology grade, TNM and clinical stage(AJCC 8th edition), 40 cases/80 cores (cores size 1.5mm)replacing LC814b.

Description: Lung cancer tissue array with matched metastatic lymph node, 40 cases/80 cores, replacing LC814

Description: Stomach cancer with matched lymph node metastasis tissue array, including pathology grade, TNM and clinical stage, 40cases/ 80cores, replacing ST810c

Description: Esophagus cancer with matched lymph node metastasis tissue array, including TNM and pathology grade, 40 cases/80 cores, replacing ES810a

Description: Lymph node diffuse large B cell lymphoma (DLBCL) tissue array, 30 cases/30 cores

Description: Lymphoma tissue array with normal lymph node tissue as control, 80 cases/ 80 cores,no overlapping with LY800b

Description: Breast cancer tissue array with lymph node positive and negative, including TNM, clinical stage and pathology grade, 98cases/ 110cores (core size 1.0mm)