Description: This gene encodes a membrane-bound protein which is a member of the ELO family, proteins which participate in the biosynthesis of fatty acids. Consistent with the expression of the encoded protein in photoreceptor cells of the retina, mutations and small deletions in this gene are associated with Stargardt-like macular dystrophy (STGD3) and autosomal dominant Stargardt-like macular dystrophy (ADMD), also referred to as autosomal dominant atrophic macular degeneration.

Description: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.

Description: GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family. Several transcript variants encoding different isoforms have been found for this gene.

Description: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.

Description: This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.

Description: The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene.

Description: The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.

Description: This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.

Description: This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.

Description: This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation.

Description: This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone.

Description: This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer.

Description: This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development.

Description: Na+ CP-pan Rabbit Polyclonal Antibody

Description: Na+ CP-pan Rabbit Polyclonal Antibody

Description: Mouse monoclonal Na, K ATPase antibody

Description: Rabbit polyclonal Na+ / I Symporter NIS) antibody

Description: Mouse monoclonal Na+ Ca2+ Exchanger antibody

Description: Na+ CP type IIα Rabbit Polyclonal Antibody

Description: Na+ CP type IIα Rabbit Polyclonal Antibody

Description: Na+ CP type IVα Rabbit Polyclonal Antibody

Description: Na+ CP type IVα Rabbit Polyclonal Antibody

Description: Na+ CP type IXα Rabbit Polyclonal Antibody

Description: Na+ CP type IXα Rabbit Polyclonal Antibody

Description: Na+ CP type IIβ Rabbit Polyclonal Antibody

Description: Na+ CP type IIβ Rabbit Polyclonal Antibody

Description: Na+ CP type IIα Rabbit Polyclonal Antibody

Description: Na+ CP type IIα Rabbit Polyclonal Antibody

Description: Rabbit polyclonal to Na+ CP-pan.

Description: Na+/K+-ATPase α1 Rabbit Polyclonal Antibody

Description: Na+/K+-ATPase α1 Rabbit Polyclonal Antibody

Description: Na+/K+-ATPase α1 Rabbit Polyclonal Antibody

Description: Na+/K+-ATPase α1 Rabbit Polyclonal Antibody

Description: Na+ CP type VIIα Rabbit Polyclonal Antibody

Description: Na+ CP type VIIα Rabbit Polyclonal Antibody

Description: Na+/K+-ATPase α2 Rabbit Polyclonal Antibody

Description: Na+/K+-ATPase α2 Rabbit Polyclonal Antibody

Description: Na+/K+-ATPase α1 Rabbit Polyclonal Antibody

Description: Na+/K+-ATPase α1 Rabbit Polyclonal Antibody

Description: Na+/K+-ATPase α1 Rabbit Polyclonal Antibody

Description: Na+/K+-ATPase α1 Rabbit Polyclonal Antibody

Description: Available in various conjugation types.