Glycolysis is the metabolic pathway that converts glucose into pyruvate, whereas fermentation can then produce lactate from pyruvate. Here, we developed single fluorescent protein (FP)-based lactate and pyruvate indicators with low EC50 for hint detection of metabolic molecules and live cell imaging and named them “Green Lindoblum” and “Green Pegassos,” respectively.
Green Lindoblum (EC50 of 30 µM for lactate) and Green Pegassos (EC50 of 70 µM for pyruvate) produced a 5.2- and 3.3-fold change in fluorescence depth in response to lactate and pyruvate, respectively. Green Lindoblum measured lactate ranges in mouse plasma, and Green Pegassos together with D-serine dehydratase efficiently estimated D-serine ranges launched from mouse main cultured neurons and astrocytes by measuring pyruvate degree.
Furthermore, live cell imaging evaluation revealed their utility for dual-colour imaging, and the interaction between lactate, pyruvate, and Ca2+ in human induced pluripotent stem cell-derived cardiomyocytes. Therefore, Green Lindoblum and Green Pegassos might be helpful instruments that detect particular molecules in scientific use and monitor the interaction of metabolites and different associated molecules in various cell varieties.
Promoter Pull-Down Assay: A Biochemical Screen for DNA-Binding Proteins
Transcription components are ubiquitous proteins that affiliate with promoter DNA and regulate gene expression by way of quite a lot of mechanisms. Understanding transcriptional management mechanisms requires in-depth investigation of the binding of transcription components to the promoters they regulate.
There are many in vivo and in vitro strategies for testing the binding of a identified protein to a promoter, reminiscent of chromatin immunoprecipitation and electrophoretic mobility shift assays. However, for these experiments, one will need to have a protein candidate to check and is just not capable of determine unknown proteins sure to a selected promoter.
Thus, the promoter pull-down assay was developed to fill this void. This technique makes use of DNA as bait to seize proteins that bind to a particular promoter, reminiscent of transcription components, from mobile lysates. Coupled with different experiments, the promoter pull-down assay vastly improves the repertoire of strategies obtainable for defining regulatory complexes that affect transcription.
Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay
Inappropriate activation of endosomal TLR7 and TLR8 happens in a number of autoimmune illnesses, particularly systemic lupus erythematosus (SLE). Herein, the event of a TLR8 antagonist competitors assay and its software for hit era of twin TLR7/Eight antagonists are reported.
The structure-guided optimization of the pyridone hit <b>3</b> utilizing this biochemical assay together with mobile and TLR8 cocrystal structural information resulted within the identification of a extremely potent and selective TLR7/Eight antagonist (<b>27</b>) with <i>in vivo</i> efficacy.
The two key steps for optimization have been (i) a core morph guided by a TLR7 sequence alignment to attain a twin TLR7/Eight antagonism profile and (ii) introduction of a fluorine within the piperidine ring to scale back its basicity, leading to enticing oral pharmacokinetic (PK) properties and improved TLR8 binding affinity.
Hunting monolignol transporters: membrane proteomics and biochemical transport assays with membrane vesicles of Norway spruce
Monolignol transport throughout lignification is {a partially} solved puzzle: each the mechanism(s) and the transported type of monolignols are unknown in creating xylem of timber. We examined a speculation of an energetic, plasma membrane (PM)-localized transport of monolignol monomers, dimers, and/or glucosidic types with membrane vesicles ready of creating xylem and lignin-forming tissue-cultured cells of Norway spruce (Picea abies L. Karst.), in addition to of management supplies, non-lignifying Norway spruce phloem and tobacco (Nicotiana tabacum L.) BY-2 cells. Xylem and BY-2 vesicles transported each coniferin and p-coumaryl alcohol glucoside, however inhibitor assays prompt this transport being over the tonoplast.
Also membrane vesicles ready from the lignin-forming spruce cells confirmed coniferin transport, however the Km for coniferin was a lot increased than these of xylem and BY-2 cells. Liquid chromatography-mass spectrometry (LC-MS/MS) evaluation of membrane proteins remoted from spruce creating xylem, phloem and lignin-forming cultured cells revealed a number of transporters.
These have been in comparison with a transporter gene set that was gained by a correlation evaluation with a particular set of spruce monolignol biosynthesis genes. Biochemical membrane vesicle assays confirmed no help for the ABC-transporter-mediated monolignol transport however level to secondary energetic transporters (reminiscent of MFS or MATE transporters). In distinction, proteomic and co-expression analyses counsel a job for ABC transporters and MFS transporters.
Protective Mechanism of Acacia saligna Butanol Extract and Its Nano-Formulations in opposition to Ulcerative Colitis in Rats as Revealed by way of Biochemical and Metabolomic Assays
Ulcerative colitis (UC) is a relapsing inflammatory illness of unknown etiology. The elevated danger of most cancers in UC sufferers warrants for the event of novel drug remedies. Herein, this work issues with the investigation of the protecting results of Acacia saligna butanol extract (ASBE) and its nanoformulations on UC in a rat mannequin and its underlying mechanism. Colitis was induced by gradual intrarectal infusion of two mL of 4% (v/v in 0.9% saline) acetic acid. Colon samples have been evaluated macroscopically, microscopically, and assayed for pro-inflammatory cytokine ranges.
To monitor related metabolic adjustments in acetic acid-induced UC mannequin, serum samples have been analyzed for main metabolites utilizing GC-MS adopted by multivariate information analyses. Treatment with ASBE attenuated acetic acid-induced UC as revealed by discount of colon weight, ulcer space, and ulcer index.
ASBE remedy additionally decreased Cyclooxygenase-2 (COX-2), Prostaglandin E2 (PGE2) & Interleukin-1β (IL-1β) ranges within the infected colon. The nano-formulation of ASBE confirmed higher safety than the crude extract in opposition to ulcer indices, elevated PGE2 manufacturing, and histopathological alterations reminiscent of intestinal mucosal lesions and inflammatory infiltration.
Distinct metabolite adjustments have been recorded in colitis rats together with a lower in oleamide and arachidonic acid together with elevated ranges of lactic acid, fructose, and pyroglutamic acid.
 ELISA Kit) Mouse Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit |
|
RD-bACE1-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 489 |
Mouse Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit |
|
RD-bACE1-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 677 |
 ELISA Kit) Rat Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit |
|
RD-bACE1-Ra-48Tests |
Reddot Biotech |
48 Tests |
EUR 511 |
Rat Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit |
|
RD-bACE1-Ra-96Tests |
Reddot Biotech |
96 Tests |
EUR 709 |
 ELISA Kit) Human Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit |
|
RDR-bACE1-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 500 |
Human Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit |
|
RDR-bACE1-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 692 |
Mouse Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit |
|
RDR-bACE1-Mu-48Tests |
Reddot Biotech |
48 Tests |
EUR 511 |
Mouse Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit |
|
RDR-bACE1-Mu-96Tests |
Reddot Biotech |
96 Tests |
EUR 709 |
Rat Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit |
|
RDR-bACE1-Ra-48Tests |
Reddot Biotech |
48 Tests |
EUR 534 |
Rat Beta-Site APP Cleaving Enzyme 1 (bACE1) ELISA Kit |
|
RDR-bACE1-Ra-96Tests |
Reddot Biotech |
96 Tests |
EUR 742 |
 Custom Antibody titration by ELISA up to 2 rabbits and 1 bleed |
|
ELISA-1 |
Alpha Diagnostics |
1 |
EUR 202 |
 Pipette Stand Starter Kits |
|
P7700-S1 |
BenchMark |
1 PC |
EUR 507.83 |
|
|
Pipette Stand Starter Kits |
|
P7700-S2 |
BenchMark |
1 PC |
EUR 526.1 |
|
|
 Basic Cytotoxicity Test Kits |
|
CT17001 |
Neuromics |
125 Tests |
EUR 409 |
Basic Cytotoxicity Test Kits |
|
CT17002 |
Neuromics |
250 Tests |
EUR 650 |
 Total Cytotoxicity Test Kits |
|
CT17003 |
Neuromics |
125 Tests |
EUR 513 |
Total Cytotoxicity Test Kits |
|
CT17004 |
Neuromics |
250 Tests |
EUR 813 |
 Necrosis vs Apoptosis Kits |
|
KF17371 |
Neuromics |
50-100 Tests |
EUR 435 |
Necrosis vs Apoptosis Kits |
|
KF17372 |
Neuromics |
100-200 Tests |
EUR 768 |
 Sheep BACE1 ELISA Kit |
|
ESB0322 |
Abclonal |
96Tests |
EUR 521 |
 Mouse bACE1 ELISA Kit |
|
EMB0322 |
Abclonal |
96Tests |
EUR 521 |
 Monkey BACE1 ELISA Kit |
|
EMKB0322 |
Abclonal |
96Tests |
EUR 521 |
 Porcine BACE1 ELISA Kit |
|
EPB0322 |
Abclonal |
96Tests |
EUR 521 |
 Rat BACE1 ELISA Kit |
|
ERB0322 |
Abclonal |
96Tests |
EUR 521 |
 Rabbit BACE1 ELISA Kit |
|
ERTB0322 |
Abclonal |
96Tests |
EUR 521 |
 Anserini bACE1 ELISA Kit |
|
EAB0322 |
Abclonal |
96Tests |
EUR 521 |
 Goat BACE1 ELISA Kit |
|
EGTB0322 |
Abclonal |
96Tests |
EUR 521 |
 Canine BACE1 ELISA Kit |
|
ECB0322 |
Abclonal |
96Tests |
EUR 521 |
 Chicken BACE1 ELISA Kit |
|
ECKB0322 |
Abclonal |
96Tests |
EUR 521 |
 Human BACE1 ELISA Kit |
|
EHB0322 |
Abclonal |
96Tests |
EUR 521 |
 Bovine BACE1 ELISA Kit |
|
EBB0322 |
Abclonal |
96Tests |
EUR 521 |
 BACE1 antibody |
|
70R-7276 |
Fitzgerald |
50 ug |
EUR 467 |
|
Description: Rabbit polyclonal BACE1 antibody raised against the N terminal of BACE1 |
 Bace1 antibody |
|
70R-8662 |
Fitzgerald |
50 ug |
EUR 467 |
|
Description: Affinity purified rabbit polyclonal Bace1 antibody |
 anti-BACE1 |
|
YF-PA17994 |
Abfrontier |
100 ug |
EUR 403 |
|
Description: Rabbit polyclonal to BACE1 |
BACE1 antibody |
|
20R-BR014 |
Fitzgerald |
50 ug |
EUR 656 |
|
Description: Rabbit polyclonal BACE1 antibody |
BACE1 antibody |
|
20R-BR015 |
Fitzgerald |
50 ug |
EUR 656 |
|
Description: Rabbit polyclonal BACE1 antibody |
BACE1 antibody |
|
70R-15953 |
Fitzgerald |
50 ul |
EUR 435 |
|
Description: Rabbit polyclonal BACE1 antibody |
 BACE1 Antibody |
|
DF7939 |
Affbiotech |
200ul |
EUR 304 |
|
Description: BACE1 Antibody detects endogenous levels of total BACE1. |
BACE1 Antibody |
|
1-CSB-PA150463 |
Cusabio |
|
|
|
|
|
Description: A polyclonal antibody against BACE1. Recognizes BACE1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;ELISA:1:2000-1:5000, WB:1:500-1:2000 |
BACE1 Antibody |
|
1-CSB-PA173556 |
Cusabio |
|
|
|
|
|
Description: A polyclonal antibody against BACE1. Recognizes BACE1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:15-1:50 |
BACE1 Antibody |
|
1-CSB-PA008418 |
Cusabio |
|
|
|
|
|
Description: A polyclonal antibody against BACE1. Recognizes BACE1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/5000 |
BACE1 Antibody |
|
1-CSB-PA002524GA01HU |
Cusabio |
|
|
|
|
|
Description: A polyclonal antibody against BACE1. Recognizes BACE1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB |
BACE1 Antibody |
|
1-CSB-PA002524LA01HU |
Cusabio |
|
|
|
|
|
Description: A polyclonal antibody against BACE1. Recognizes BACE1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200 |
 BACE1 protein |
|
E62B011 |
EnoGene |
20ug |
EUR 343 |
BACE1 Antibody |
|
35650-100ul |
SAB |
100ul |
EUR 252 |
 bACE1 siRNA |
|
20-abx900582 |
Abbexa |
|
|
|
|
bACE1 siRNA |
|
20-abx908826 |
Abbexa |
|
|
|
|
bACE1 siRNA |
|
20-abx908827 |
Abbexa |
|
|
|
|
 Rat Neural Stem Cell Kits |
|
PC37123 |
Neuromics |
1 X 10(6) *minimum order 6 vials* |
EUR 957 |
 MitoPT™ TMRE & TMRM Kits |
|
KF17358 |
Neuromics |
500 Test |
EUR 479 |
MitoPT™ TMRE & TMRM Kits |
|
KF17359 |
Neuromics |
500 Test |
EUR 479 |
) HISTAR DETECTION SYSTEM Kits (OKSA11259) |
|
OKSA11259 |
Aviva Systems Biology |
50 Tests |
EUR 565 |
|
Description: Description of target: HISTAR DETECTION SYSTEM;Species reactivity: ;Application: IHC-AFF, IHC-FFPE;Assay info: ;Sensitivity: |
) HISTAR DETECTION SYSTEM Kits (OKSA11260) |
|
OKSA11260 |
Aviva Systems Biology |
150 Tests |
EUR 1335 |
|
Description: Description of target: HISTAR DETECTION SYSTEM;Species reactivity: ;Application: IHC-AFF, IHC-FFPE;Assay info: ;Sensitivity: |
) HISTAR DETECTION SYSTEM Kits (OKSA11261) |
|
OKSA11261 |
Aviva Systems Biology |
500 Tests |
EUR 2019 |
|
Description: Description of target: HISTAR DETECTION SYSTEM;Species reactivity: ;Application: IHC-AFF, IHC-FFPE;Assay info: ;Sensitivity: |
 Guinea Pig BACE1 ELISA Kit |
|
EGB0322 |
Abclonal |
96Tests |
EUR 521 |
 (OKCD02313)) BACE1 ELISA Kit (Rat) (OKCD02313) |
|
OKCD02313 |
Aviva Systems Biology |
96 Wells |
EUR 818 |
|
Description: Description of target: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. ;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.7 pg/mL |
 (OKEH03206)) BACE1 ELISA Kit (Mouse) (OKEH03206) |
|
OKEH03206 |
Aviva Systems Biology |
96 Wells |
EUR 662 |
|
Description: Description of target: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.39 ng/mL |
 (OKCD06723)) BACE1 ELISA Kit (Human) (OKCD06723) |
|
OKCD06723 |
Aviva Systems Biology |
96 Wells |
EUR 753 |
|
Description: Description of target: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein. BACE1, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 0.11ng/mL |
 (OKCD06724)) BACE1 ELISA Kit (Mouse) (OKCD06724) |
|
OKCD06724 |
Aviva Systems Biology |
96 Wells |
EUR 779 |
|
Description: Description of target: Bace1 is responsible for the proteolytic processing of the amyloid precursor protein (APP). Bace1 cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 12.1pg/mL |
 (OKAN05558)) BACE1 ELISA Kit (Human) (OKAN05558) |
|
OKAN05558 |
Aviva Systems Biology |
96 Wells |
EUR 792 |
|
Description: Description of target: This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.11 ng/mL |
 (OKAN05559)) BACE1 ELISA Kit (Mouse) (OKAN05559) |
|
OKAN05559 |
Aviva Systems Biology |
96 Wells |
EUR 792 |
|
Description: Description of target: This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. Homozygous knockout mice for this gene exhibit a wide range of nervous system defects, growth retardation, metabolic abnormalities, and increased neonatal lethality.;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 14.1 pg/mL |
 BACE1 Blocking Peptide |
|
33R-3496 |
Fitzgerald |
100 ug |
EUR 180 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of BACE1 antibody, catalog no. 70R-7276 |
BACE1 Blocking Peptide |
|
DF7939-BP |
Affbiotech |
1mg |
EUR 195 |
 BACE1 cloning plasmid |
|
CSB-CL002524HU-10ug |
Cusabio |
10ug |
EUR 531 |
|
|
|
Description: A cloning plasmid for the BACE1 gene. |
 Antibody) bACE1 (pS498) Antibody |
|
abx148520-100ug |
Abbexa |
100 ug |
EUR 439 |
|
|
 BACE1 Rabbit pAb |
|
A5266-100ul |
Abclonal |
100 ul |
EUR 308 |
BACE1 Rabbit pAb |
|
A5266-200ul |
Abclonal |
200 ul |
EUR 459 |
BACE1 Rabbit pAb |
|
A5266-20ul |
Abclonal |
20 ul |
EUR 183 |
BACE1 Rabbit pAb |
|
A5266-50ul |
Abclonal |
50 ul |
EUR 223 |
 Anti-BACE1 antibody |
|
STJ29911 |
St John's Laboratory |
100 µl |
EUR 277 |
|
Description: This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. |
 Polyclonal BACE1 Antibody |
|
APG03188G |
Leading Biology |
0.1mg |
EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BACE1 . This antibody is tested and proven to work in the following applications: |
 BACE1 Polyclonal Antibody |
|
ABP-PAB-31005 |
Allele Biotech |
50 ug |
Ask for price |
|
|
BACE1 Polyclonal Antibody |
|
ABP-PAB-31006 |
Allele Biotech |
50 ug |
Ask for price |
|
|
 BACE1 Conjugated Antibody |
|
C35650 |
SAB |
100ul |
EUR 397 |
 anti- BACE1 antibody |
|
FNab00781 |
FN Test |
100µg |
EUR 548.75 |
|
|
|
Description: Antibody raised against BACE1 |
 Recombinant Human BACE1 |
|
P0562 |
FN Test |
100ug |
EUR 522.36 |
|
|
|
Description: Recombinant Human protein for BACE1 |
 CellQuanti-Blue Cell Viability Assay Kits |
|
CQBL-05K |
BioAssay Systems |
5000 |
EUR 221 |
|
Description: Homogeneous assay for cell viability, proliferation, cytotoxcity, high-throµghput screening for anticancer agents. Fluorimetric method (530nm/590nm). Kit size: 5000 tests. Shelf life: 12 months. Shipping: ambient temp; storage: 4°C. |
CellQuanti-Blue Cell Viability Assay Kits |
|
CQBL-10K |
BioAssay Systems |
10000 |
EUR 340 |
|
Description: Homogeneous assay for cell viability, proliferation, cytotoxcity, high-throµghput screening for anticancer agents. Fluorimetric method (530nm/590nm). Kit size: 10000 tests. Shelf life: 12 months. Shipping: ambient temp; storage: 4°C. |
 CellQuanti-MTT Cell Viability Assay Kits |
|
CQMT-500 |
BioAssay Systems |
500 |
EUR 210 |
|
Description: Colorimetric (570nm) assay for cell viability, proliferation, cytotoxcity, HTS for anticancer agents. Kit size: 500 tests. Shelf life: 12 months. Shipping: ambient temp; storage: 4, -20°C. |
) MITOCHONDRIAL MEMBRANE POTENTIAL KIT Kits (OKSA11298) |
|
OKSA11298 |
Aviva Systems Biology |
500 Tests |
EUR 956 |
|
Description: Description of target: MITOCHONDRIAL MEMBRANE POTENTIAL KIT ;Species reactivity: Human;Application: FC, IF;Assay info: ;Sensitivity: |
) MITOCHONDRIAL MEMBRANE POTENTIAL KIT Kits (OKSA11300) |
|
OKSA11300 |
Aviva Systems Biology |
500 Tests |
EUR 956 |
|
Description: Description of target: MITOCHONDRIAL MEMBRANE POTENTIAL KIT ;Species reactivity: Human;Application: FC, IF;Assay info: ;Sensitivity: |
 BACE1 recombinant monoclonal antibody |
|
A5095 |
Bimake |
100ul X 3 |
EUR 595 |
|
|
|
Description: A recombinant monoclonal antibody from rabbit against human BACE1 for WB,ELISA |
 BACE1 Antibody, HRP conjugated |
|
1-CSB-PA002524LB01HU |
Cusabio |
|
|
|
|
|
Description: A polyclonal antibody against BACE1. Recognizes BACE1 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
 BACE1 Antibody, FITC conjugated |
|
1-CSB-PA002524LC01HU |
Cusabio |
|
|
|
|
|
Description: A polyclonal antibody against BACE1. Recognizes BACE1 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
 BACE1 Antibody, Biotin conjugated |
|
1-CSB-PA002524LD01HU |
Cusabio |
|
|
|
|
|
Description: A polyclonal antibody against BACE1. Recognizes BACE1 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
) BACE1 Recombinant Protein (Human) |
|
RP002572 |
ABM |
100 ug |
Ask for price |
) BACE1 Recombinant Protein (Mouse) |
|
RP118622 |
ABM |
100 ug |
Ask for price |
BACE1 Recombinant Protein (Mouse) |
|
RP118625 |
ABM |
100 ug |
Ask for price |
) BACE1 Recombinant Protein (Rat) |
|
RP191804 |
ABM |
100 ug |
Ask for price |
 Mouse BACE1 shRNA Plasmid |
|
20-abx973511 |
Abbexa |
|
|
|
|
 Rat BACE1 shRNA Plasmid |
|
20-abx985469 |
Abbexa |
|
|
|
|
 Human BACE1 shRNA Plasmid |
|
20-abx958402 |
Abbexa |
|
|
|
|
 Rat Bace1/ Beta-secretase 1 ELISA Kit |
|
E0115Ra |
Sunlong |
1 Kit |
EUR 571 |
 Mouse Bace1/ Beta-secretase 1 ELISA Kit |
|
E0159Mo |
Sunlong |
1 Kit |
EUR 571 |
 Human BACE1/ Beta-secretase 1 ELISA Kit |
|
E0249Hu |
Sunlong |
1 Kit |
EUR 571 |
 : 96 Wells (OKEH00554)) BACE1 ELISA Kit (Human) : 96 Wells (OKEH00554) |
|
OKEH00554 |
Aviva Systems Biology |
96 Wells |
EUR 662 |
|
Description: Description of target: This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015];Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.31 ng/mL |
 ELISA Kit) Mouse Bace1(Beta-secretase 1) ELISA Kit |
|
EM0448 |
FN Test |
96T |
EUR 524.1 |
|
|
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.094 ng/ml |
 (pORF)) Bace1 ORF Vector (Rat) (pORF) |
|
ORF063936 |
ABM |
1.0 ug DNA |
EUR 506 |
 (pORF)) BACE1 ORF Vector (Human) (pORF) |
|
ORF000858 |
ABM |
1.0 ug DNA |
EUR 95 |
 (pORF)) Bace1 ORF Vector (Mouse) (pORF) |
|
ORF039542 |
ABM |
1.0 ug DNA |
EUR 506 |
Bace1 ORF Vector (Mouse) (pORF) |
|
ORF039543 |
ABM |
1.0 ug DNA |
EUR 506 |
) Polyclonal BACE1 / BACE Antibody (Internal) |
|
APR11484G |
Leading Biology |
0.05mg |
EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BACE1 / BACE (Internal). This antibody is tested and proven to work in the following applications: |
 Monoclonal BACE1 Antibody, Clone: 3C1C3 |
|
APR15123G |
Leading Biology |
0.1ml |
EUR 528 |
|
Description: A Monoclonal antibody against Human BACE1. The antibodies are raised in Mouse and are from clone 3C1C3. This antibody is applicable in WB, FC, ICC, E |
 Recombinant Human BACE1/ASP2 Protein |
|
RP00165 |
Abclonal |
20 μg |
EUR 183 |
) Polyclonal BACE1 Antibody (N-term) |
|
APG03026G |
Leading Biology |
0.1ml |
EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BACE1 (N-term). This antibody is tested and proven to work in the following applications: |
 Polyclonal Bace1 antibody - middle region |
|
APG03189G |
Leading Biology |
0.05mg |
EUR 528 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Bace1 - middle region. This antibody is tested and proven to work in the following applications: |
 Bace1 ELISA Kit| Mouse Beta-secretase 1 ELISA Kit |
|
EF013095 |
Lifescience Market |
96 Tests |
EUR 689 |
 Antibody) Mast/stem Cell Growth Factor Receptor Kit (Kits) Antibody |
|
20-abx116620 |
Abbexa |
|
|
|
|
) Rabbit ANTI 14-3-3 ISOFORM PANEL Kits (OKSA11258) |
|
OKSA11258 |
Aviva Systems Biology |
1 u |
EUR 1236 |
|
Description: Description of target: RABBIT ANTI 14-3-3 ISOFORM PANEL;Species reactivity: Sheep;Application: ELISA, IHC-FFPE, WB;Assay info: ;Sensitivity: |
) Human CellExp? BACE1, human recombinant (Native) |
|
7398-10 |
Biovision |
|
EUR 300 |
Human CellExp? BACE1, human recombinant (Native) |
|
7398-50 |
Biovision |
|
EUR 827 |
 (pORF)) BACE1-AS ORF Vector (Human) (pORF) |
|
ORF016079 |
ABM |
1.0 ug DNA |
Ask for price |
) Bace1 sgRNA CRISPR Lentivector set (Mouse) |
|
K5021101 |
ABM |
3 x 1.0 ug |
EUR 339 |
) Bace1 sgRNA CRISPR Lentivector set (Rat) |
|
K6778001 |
ABM |
3 x 1.0 ug |
EUR 339 |
) BACE1 sgRNA CRISPR Lentivector set (Human) |
|
K0166201 |
ABM |
3 x 1.0 ug |
EUR 339 |
 Activity Assay Kit (Fluorometric)) ?-Secretase (BACE1) Activity Assay Kit (Fluorometric) |
|
K388-100 |
Biovision |
|
EUR 604 |
 Anti-BACE1/Bace Rabbit Monoclonal Antibody |
|
M00322 |
BosterBio |
100ug/vial |
EUR 397 |
|
Description: Rabbit Monoclonal BACE1/Bace Antibody. Validated in IP, WB and tested in Human, Mouse, Rat. |
) Polyclonal BACE1 / BACE Antibody (C-Terminus) |
|
AMM05613G |
Leading Biology |
0.05mg |
EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BACE1 / BACE (C-Terminus). This antibody is tested and proven to work in the following applications: |
 IgM capture ELISA kits, 96 tests, qualitative) Human Anti-Chikungunya virus (CHIKV) IgM capture ELISA kits, 96 tests, qualitative |
|
910-705-CHM |
Alpha Diagnostics |
1 Kit |
EUR 834 |
 BACE1 3'UTR Luciferase Stable Cell Line |
|
TU001601 |
ABM |
1.0 ml |
EUR 2333 |
 Bace1 3'UTR GFP Stable Cell Line |
|
TU152500 |
ABM |
1.0 ml |
Ask for price |
 Bace1 3'UTR Luciferase Stable Cell Line |
|
TU102500 |
ABM |
1.0 ml |
Ask for price |
Bace1 3'UTR Luciferase Stable Cell Line |
|
TU201202 |
ABM |
1.0 ml |
Ask for price |
Bace1 3'UTR GFP Stable Cell Line |
|
TU251202 |
ABM |
1.0 ml |
Ask for price |
 BACE1 3'UTR GFP Stable Cell Line |
|
TU051601 |
ABM |
1.0 ml |
EUR 2333 |
 (pPB-C-His)) BACE1 Protein Vector (Mouse) (pPB-C-His) |
|
PV158166 |
ABM |
500 ng |
EUR 603 |
 (pPB-N-His)) BACE1 Protein Vector (Mouse) (pPB-N-His) |
|
PV158167 |
ABM |
500 ng |
EUR 603 |
 (pPM-C-HA)) BACE1 Protein Vector (Mouse) (pPM-C-HA) |
|
PV158168 |
ABM |
500 ng |
EUR 603 |
 (pPM-C-His)) BACE1 Protein Vector (Mouse) (pPM-C-His) |
|
PV158169 |
ABM |
500 ng |
EUR 603 |
BACE1 Protein Vector (Mouse) (pPB-C-His) |
|
PV158170 |
ABM |
500 ng |
EUR 603 |
BACE1 Protein Vector (Mouse) (pPB-N-His) |
|
PV158171 |
ABM |
500 ng |
EUR 603 |
BACE1 Protein Vector (Mouse) (pPM-C-HA) |
|
PV158172 |
ABM |
500 ng |
EUR 603 |
BACE1 Protein Vector (Mouse) (pPM-C-His) |
|
PV158173 |
ABM |
500 ng |
EUR 603 |
 (pPB-C-His)) BACE1 Protein Vector (Rat) (pPB-C-His) |
|
PV255742 |
ABM |
500 ng |
EUR 603 |
 (pPB-N-His)) BACE1 Protein Vector (Rat) (pPB-N-His) |
|
PV255743 |
ABM |
500 ng |
EUR 603 |
 (pPM-C-HA)) BACE1 Protein Vector (Rat) (pPM-C-HA) |
|
PV255744 |
ABM |
500 ng |
EUR 603 |
 (pPM-C-His)) BACE1 Protein Vector (Rat) (pPM-C-His) |
|
PV255745 |
ABM |
500 ng |
EUR 603 |
 (pPB-His-MBP)) BACE1 Protein Vector (Human) (pPB-His-MBP) |
|
PV326078 |
ABM |
500 ng |
EUR 329 |
 (pPB-His-GST)) BACE1 Protein Vector (Human) (pPB-His-GST) |
|
PV326079 |
ABM |
500 ng |
EUR 329 |
BACE1 Protein Vector (Human) (pPB-His-MBP) |
|
PV326082 |
ABM |
500 ng |
EUR 329 |
Treatment with nano extract restored metabolite ranges to regular and means that cytokine ranges have been regulated by nano extract in UC. Conclusion: ASBE nano extract mitigated in opposition to acetic acid-induced colitis in rats, and the underlying mechanism might be attributed to the modulatory results of ASBE on the inflammatory cascades. The applicability of metabolomics developed on this rat mannequin appears to be essential for evaluating the anti-inflammatory mechanisms of latest therapeutics for acute colitis.
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