Description: A polyclonal antibody raised in Mouse that recognizes and binds to Human CXorf26 (chromosome X open reading frame 26) . This antibody is tested and proven to work in the following applications:

Description: Affinity purified rabbit polyclonal antibody reactive to BDBV GP (detects recombinant BDBV GP without the transmembrane region (BDBV rGPdTM))

Description: anti-CD22 monoclonal antibody

Description: anti-CD22 monoclonal antibody

Description: Rabbit polyclonal reactive to S. aureus alpha hemolysin

Description: Protein A purified rabbit polyclonal antibody reactive to S. aureus LukA

Description: Protein A purified rabbit polyclonal antibody reactive to S. aureus LukB

Description: The CD4 gene encodes the T4 antigen, a glycoprotein of approximately 55 kDa, expressed on the surface of helper T lymphocytes.CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in major histocompatibility complex class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as interleukin-15 receptors and bind to the HIV receptors, binding directly to the HIV envelope protein GP120.

Description: CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell-antigen interactions. Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the MHC class I protein. There are two isoforms of the protein, alpha and beta, each encoded by a different gene. In humans, both genes are located on chromosome 2 in position 2p12. The CD8 co-receptor is predominantly expressed on the surface of cytotoxic T cells, but can also be found on natural killer cells, cortical thymocytes, and dendritic cells. The CD8 molecule is a marker for cytotoxic T cell population. It is expressed in T cell lymphoblastic lymphoma and hypo-pigmented mycosis fungoides. The extracellular IgV-like domain of CD8-α interacts with the α3 portion of the Class I MHC molecule. This affinity keeps the T cell receptor of the cytotoxic T cell and the target cell bound closely together during antigen-specific activation. Cytotoxic T cells with CD8 surface protein are called CD8+ T cells. The main recognition site is a flexible loop at the α3 domain of an MHC molecule. This was discovered by doing mutational analyses. The flexible α3 domain is located between residues 223 and 229 in the genome. In addition to aiding with cytotoxic T cell antigen interactions the CD8 co-receptor also plays a role in T cell signaling. The cytoplasmic tails of the CD8 co-receptor interact with Lck (lymphocyte-specific protein tyrosine kinase). Once the T cell receptor binds its specific antigen Lck phosphorylates the cytoplasmic CD3 and ζ-chains of the TCR complex which initiates a cascade of phosphorylation eventually leading to activation of transcription factors like NFAT, NF-κB, and AP-1 which affect the expression of certain genes.

Description: Rabbit polyclonal for Junin vaccine strain Candid #1

Description: CD34 is a transmembrane phosphoglycoprotein protein encoded by the CD34 gene in humans, mice, rats and other species. The CD34 protein is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early haematopoietic and vascular-associated progenitor cells. However, little is known about its exact function. CD34 is also an important adhesion molecule and is required for T cells to enter lymph nodes. It is expressed on lymph node endothelia, whereas the L-selectin to which it binds is on the T cell. Conversely, under other circumstances CD34 has been shown to act as molecular "Teflon" and block mast cell, eosinophil and dendritic cell precursor adhesion, and to facilitate opening of vascular lumina. Finally, recent data suggest CD34 may also play a more selective role in chemokine-dependent migration of eosinophils and dendritic cell precursors. Regardless of its mode of action, under all circumstances CD34, and its relatives podocalyxin and endoglycan, facilitates cell migration.

Description: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascad.

Description: DPPA2 (developmental pluripotency associated 2) is an embryo-cancer antigen that is coexpressed with cancer-testis antigens in non-small cell lung cancer. Dppa2 is closely linked SAP motif genes restricted to pluripotent cells and the germ line. It may play a role in maintaining cell pluripotentiality and in embryo preimplantation development.

Description: Rabbit polyclonal antibody against Junin virus

Description: Rabbit polyclonal antibody reactive to the S. aureus Hlg B with His tag

Description: Rabbit polyclonal antibody reactive to the S. aureus Hlg C with His tag

Description: Affinity purified rabbit polyclonal antibody against EBOV NP (detects EBOV NP in virus-like particles (VLP))

Description: Affinity purified rabbit polyclonal antibody against EBOV GP (detects EBOV GP in virus-like particles (VLP) and recombinant EBOV GP without the transmembrane region)

Description: Affinity purified rabbit polyclonal antibody against SUDV NP (detects SUDV NP in virus-like particles (VLP))

Description: Affinity purified rabbit polyclonal antibody against SUDV GP (detects SUDV GP in virus-like particles (VLP) and recombinant SUDV GP without the transmembrane region)

Description: Affinity purified rabbit polyclonal antibody against MARV GP (detects MARV GP in virus-like particles (VLP) and recombinant MARV GP without the transmembrane region)

Description: Affinity purified rabbit polyclonal antibody against MARV NP (detects MARV NP in virus-like particles (VLP))

Description: Affinity purified rabbit polyclonal antibody reactive to Lassa virus GP

Description: Affinity purified rabbit polyclonal antibody reactive to Lassa virus Z protein

Description: Affinity purified rabbit polyclonal antibody reactive to Zika virus E protein

Description: Affinity purifed rabbit polyclonal antibody reactive to SUDV Soluble glycoprotein (sGP)

Description: Affinity purified rabbit polyclonal antibody reactive to RESTV GP (detects recombinant RESTV GP without the transmembrane region (RESTV rGPdTM))

Description: Affinity purified rabbit polyclonal antibody reactive to CHIKV strain 181/25

Description: Affinity purified rabbit polyclonal antibody reactive to Zika virus Non-Structural protein 1

Description: Affinity purified rabbit polyclonal antibody against EBOV GP, NP, and VP40 (detects EBOV GP, NP, and VP40 in virus-like particles (VLP))

Description: Affinity purified rabbit polyclonal antibody against MARV GP, NP, and VP40 (detects MARV GP, NP, and VP40 in virus-like particles (VLP))

Description: Rabbit polyclonal antibody against Vaccinia vaccine

Description: Affinity purified rabbit polyclonal antibody against EBOV VP40 (detects EBOV VP40 in virus-like particles (VLP) and recombinant EBOV GP without the transmembrane region)

Description: Affinity purified rabbit polyclonal antibody against EBOV VP35 (detects EBOV GP in virus-like particles (VLP) and recombinant EBOV GP without the transmembrane region)

Description: Affinity purified rabbit polyclonal antibody against EBOV VP24 (detects EBOV GP in virus-like particles (VLP) and recombinant EBOV GP without the transmembrane region)

Description: Affinity purified rabbit polyclonal antibody against EBOV VP24 (detects EBOV GP in virus-like particles (VLP) and recombinant EBOV GP without the transmembrane region)

Description: Affinity purified rabbit polyclonal antibody against EBOV VP30 (detects EBOV GP in virus-like particles (VLP) and recombinant EBOV GP without the transmembrane region)

Description: Affinity purified rabbit polyclonal antibody against SUDV VP40 (detects SUDV VP40 in virus-like particles (VLP) and recombinant SUDV GP without the transmembrane region)

Description: Affinity purified rabbit polyclonal antibody against MARV VP40 (detects MARV VP40 in virus-like particles (VLP) and recombinant MARV VP40 without the transmembrane region)

Description: Rabbit polyclonal reactive to S. aureus Panton Valentine Luk-F

Description: Rabbit polyclonal reactive to S. aureus Panton Valentine Luk-S

Description: CD117 Antigen, also called KIT or C-kit receptor, is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism.

Description: Rabbit polyclonal antibody against Ebola strain Zaire

Description: Rabbit polyclonal antibody against Marburg strain Marburg

Description: Affinity purified rabbit polyclonal antibody reactive to Eastern Equine Encephalitis E2 glycoprotein

Description: Affinity purified rabbit polyclonal antibody reactive to Western Equine Encephalitis E2 glycoprotein

Description: Protein A/G purified rabbit polyclonal antibody against EBOV GP (antibody detects recombinant EBOV GP (modified) and GP expressed in virus-like particles (VLP))

Description: Cyclin D1 is a protein that in humans is encoded by the CCND1 gene. The CCND1 gene encodes the cyclin D1 protein. The human CCND1 gene is located on the long arm of chromosome 11 (band 11q13). It is 13,388 base pairs long, and translates into 295 amino acids. Cyclin D1 is expressed in all adult human tissues with the exception of cells derived from bone marrow stem cell lines (both lymphoid and myeloid). The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDKs (Cyclin-dependent kinase). Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Micrograph of cyclin D1 staining in a mantle cell lymphoma. Immunohistochemical staining of cyclin D1 antibodies is used to diagnose mantle cell lymphoma. Cyclin D1 has been found to be overexpressed in breast carcinoma. Its potential use as a biomarker was suggested.

Description: Synaptophysin is a 38 kDa glycoprotein present in the membrane of neuronal presynaptic vesicles in brain, spinal cord, retina, vesicles of adrenal medulla, neuromuscular junctions, and endocrine cells. It is also expressed by neuroendocrine cells throughout the body, both normal and neoplastic. Synaptophysin is a useful marker for the identification of normal neuroendocrine cells and neuroendocrine neoplasms.

Description: Key downstream component of the canonical Wnt signaling pathway In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling.

Description: Cadherin-1 or Epithelial cadherin (E-cadherin), (not to be confused with the APC/C activator protein CDH1) is a protein that in humans is encoded by the CDH1 gene. Mutations are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. CDH1 has also been designated as CD324 (cluster of differentiation 324). It is a tumor suppressor gene. Cadherin-1 is a classical member of the cadherin superfamily. The encoded protein is a calcium-dependent cell–cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells, and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin (epithelial) is the most well-studied member of the cadherin family. It consists of 5 cadherin repeats (EC1 ~ EC5) in the extracellular domain, one transmembrane domain, and an intracellular domain that binds p120-catenin and beta-catenin. The intracellular domain contains a highly-phosphorylated region vital to beta-catenin binding and, therefore, to E-cadherin function.

Description: Caveolin, an integral membrane protein, is a principal component of caveolae membranes in vivo. Two isoforms of caveolin have been identified: a slower migrating 24-kDa species (-isoform) and a faster migrating 21-kDa species (-isoform). Caveolins interact with multiple signaling molecules, such as the G-protein alpha subunit, tyrosine kinase receptors, PKCs, Src family tyrosine kinases and eNOS. Caveolin-1 has been implicated in the pathogenesis of mammary epithelial cell hyperplasia.

Description: anti-CD3 monoclonal antibody

Description: anti-CD3 monoclonal antibody

Description: Affinity purified rabbit polyclonal antibody reactive to EBOV Delta Peptide

Description: Rabbit polyclonal antibody broadly reactive to SEB, SEA, SEC and TSST-1

Description: Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. Keratin 18 is often used together with keratin 8 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.