COVID19-inhibitory activity of withanolides involves targeting of the host cell surface receptor ACE2: insights from computational and biochemical assays

SARS-CoV-2 outbreak in China in December 2019 and its unfold as worldwide pandemic has been a significant international well being disaster. Extremely excessive an infection and mortality charge has severely affected all sectors of life and derailed the international financial system. While drug and vaccine improvement have been prioritized and have made vital development, use of phytochemicals and natural constituents is deemed as a low-cost, safer and available different.
We investigated therapeutic efficacy of eight withanolides (derived from Ashwagandha) in opposition to the angiotensin-converting enzyme 2 (ACE2) proteins, a goal cell surface receptor for SARS-CoV-2 and report outcomes on the (i) computational analyses together with binding affinity and secure interactions with ACE2, occupancy of ACE2 residues in making polar and nonpolar interactions with totally different withanolides/ligands and (2) in vitro mRNA and protein analyses utilizing human most cancers (A549, MCF7 and HSC3) cells.
We discovered that amongst all withanolides, Withaferin-A, Withanone, Withanoside-IV and Withanoside-V considerably inhibited the ACE2 expression. Analysis of withanolides-rich aqueous extracts derived from Ashwagandha leaves and stem confirmed a better ACE2 inhibitory efficiency of stem-derived extracts. Taken collectively, we demonstrated the inhibitory efficiency of Ashwagandha withanolides and its aqueous extracts in opposition to ACE2.Communicated by Ramaswamy H. Sarma.
Spectrochemical and biochemical assay comparability research of the therapeutic impact of the Aloe vera and Hypericum perforatum loaded nanofiber dressings on diabetic wound
Diabetic wounds have a gradual therapeutic course of and straightforward to be contaminated. In addition to present drug remedies, supportive approaches are wanted for diabetic wound remedy. In this research, we aimed to load Aloe Vera (AV) and Hypericum perforatum oil (HPO) with PCL/Ge (Poly (ɛ-caprolactone)/Gelatine) polymeric biodegradable by electrospinning methodology into nanofiber dressings on an experimental diabetic wound mannequin to check the diabetic wound therapeutic impact. Changes in the quantity and chemical construction of phospholipids,
proteins, and lipids had been investigated in the blood and serum samples of the animals utilizing Fourier rework infrared (FTIR) evaluation.

To consider organic occasions related to the wound restore course of in inflammatory section we used oxidant and antioxidant standing to find out the therapeutic standing of wounds akin to Total antioxidant standing (TAS), Total oxidant stage (TOS) and tumor necrosis issue alpha (TNF-α) ranges. TOS stage elevated in DM teams and decreased in the AV and HPO group. Oxidative stress index decreased and TNF-α stage elevated in the HPO group.
FTIR spectra confirmed adjustments in the phospholipids, proteins, and carbon chain of lipids in the entire blood in addition to serum of DM rats. FTIR spectra mixed with Principal part evaluation (PCA) confirmed, that handled DM rats by AV and HPO induced return chemical construction of blood and serum to this noticed in management group. Higher similarity with management group for HPO rats was noticed. HPO is best than AV in the different for therapeutic on diabetic wound. Thus, now we have demonstrated that IR spectroscopy and multivariate information evaluation and biochemical assays are constant and correlative with one another.
Kinetic evaluation of the inhibition mechanism of bovine mitochondrial F1-ATPase inhibitory protein utilizing biochemical assay
ATPase inhibitory issue 1 (IF1) is a mitochondrial regulatory protein that blocks ATP hydrolysis of F1-ATPase, by inserting its N-terminus into the rotor-stator interface of F1-ATPase. Although earlier research have proposed a two-step mannequin for IF1-mediated inhibition, the underlying molecular mechanism stays unclear. Here, we analyzed the kinetics of IF1-mediated inhibition underneath a variety of [ATP]s and [IF1]s, utilizing bovine mitochondrial IF1 and F1-ATPase.
Typical hyperbolic curves of inhibition charges with [IF1]s had been noticed in any respect [ATP]s examined, suggesting a two-step mechanism: the preliminary affiliation of IF1 to F1-ATPase and the locking course of, the place IF1 blocks rotation by inserting its N-terminus. The preliminary affiliation was depending on ATP.
Considering two principal rotation dwells, binding dwell and catalytic dwell, in F1-ATPase, this outcome implies that IF1 associates with F1-ATPase in the catalytic-waiting state. In distinction, the isomerization course of to the locking state was nearly impartial of ATP, suggesting that it is usually impartial of the F1-ATPase state. Further, we investigated the position of Glu30 or Tyr33 of IF1 in the two-step mechanism.
Kinetic evaluation confirmed that Glu30 is concerned in the isomerization, whereas Tyr33 contributes to the preliminary affiliation. Based on the current findings, we suggest an IF1-mediated inhibition scheme.
Further analyses of APRIL/APRIL-Receptor/Glycosaminoglycan interactions by biochemical assays linked to computational research
A proliferation-inducing ligand (APRIL) is a member of the tumor necrosis issue superfamily. APRIL is kind of distinctive on this superfamily for at the least for 2 causes: i) it binds to glycosaminoglycans (GAGs) by way of its positively charged N-terminus; ii) one of its signaling receptor, the transmembrane activator CAML interactor (TACI) was additionally reported to bind GAGs. Here, as offered by biochemical evidences with the use of an APRIL deletion mutant linked to computational research, APRIL-GAG interplay concerned different areas than the APRIL N-terminus.
Preferential interplay of APRIL with heparin adopted by chondroitin sulfate E had been confirmed by in silico evaluation. Both computational and experimental approaches didn’t reveal heparan sulfate binding to TACI.
![]() beta-Amyloid P Component (27 -38), amide |
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5-00459 | CHI Scientific | 4 x 5mg | Ask for price |
![]() Amyloid Beta-Peptide (1-40) (human) |
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A1124-1 | ApexBio | 1 mg | 226.8 EUR |
Description: Amyloid ?-Peptide (1-40) (human), (C194H295N53O58S1), a peptide with the sequence H2N-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA-OH, MW= 4329.8. Amyloid beta (A? or Abeta) is a peptide of 36-43 amino acids that is processed from the Amyloid precursor protein. |
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![]() Amyloid b-Protein (1-38) |
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H-2966.0500 | Bachem | 0.5mg | 189.6 EUR |
Description: Sum Formula: C184H277N51O56S; CAS# [131438-74-9] net |
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![]() Amyloid b-Protein (1-38) |
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H-2966.1000 | Bachem | 1.0mg | 320.4 EUR |
Description: Sum Formula: C184H277N51O56S; CAS# [131438-74-9] net |
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![]() 26797 38 CLOSURE NTRL 38MM NATURAL COLOR |
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26797-38 | CORNING | 50/pk | 169.2 EUR |
Description: Disposable Screw Cap Culture Tubes; Poly Closures |
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![]() PACAP 1-38 |
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B6625-1 | ApexBio | 1 mg | 416.4 EUR |
![]() Assurance Grade Set of 38 Single-Element Standards 1000 ug/mL (1000 PPM) |
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ICP-KIT-1 | Scientific Laboratory Supplies | EACH | 1914.06 EUR |
![]() beta Amyloid P Component (27 38), amide Peptide |
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20-abx266397 | Abbexa |
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![]() Amyloid Beta-peptide (25-35) (human) |
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A1039-1 | ApexBio | 1 mg | 138 EUR |
Description: Met-Leu-Gly-Ile-Ile-Ala-Gly-Lys-Asn-Ser-GlyAmyloid- ? (A?) peptide is commonly found in human Alzheimer?s disease (AD) brain and is the main component of Alzheimer amyloid plaques. The predominant forms of A? in the human brain are A? (1-40) and A? (1-42). |
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![]() Amyloid Beta-Peptide (12-28) (human) |
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A1123-1 | ApexBio | 1 mg | 157.2 EUR |
Description: Amyloid beta (A? or Abeta) is a peptide of 36-43 amino acids that is processed from the Amyloid precursor protein. |
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![]() Human beta-Amyloid 25-35 fragment |
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BAM2535-1 | Alpha Diagnostics | 1 mg | 489.6 EUR |
![]() CORNING® REUSABLE PHENOLIC GPI 38-400 THREADED SCREW CAP WITH RUBBER LINER |
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9999-38 | CORNING | 36/pk | 266.4 EUR |
Description: General Apparatus; Stoppers |
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![]() Human Beta Amyloid ELISA Kit |
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QY-E05730 | Qayee Biotechnology | 96T | 433.2 EUR |
![]() Amyloid b-Protein (36-38) |
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H-5270.0001 | Bachem | 1.0g | 181.2 EUR |
Description: Sum Formula: C9H17N3O4; CAS# [21835-35-8] |
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![]() Amyloid b-Protein (36-38) |
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H-5270.0005 | Bachem | 5.0g | 615.6 EUR |
Description: Sum Formula: C9H17N3O4; CAS# [21835-35-8] |
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![]() Mouse beta-42(Amyloid Beta 1-42) ELISA Kit |
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STJ150004 | St John's Laboratory | 1 kit | 494.4 EUR |
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of Abeta1-42 in Mouse serum, plasma and other biological fluids |
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![]() Rat beta-40(Amyloid Beta 1-40) ELISA Kit |
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STJ150091 | St John's Laboratory | 1 kit | 494.4 EUR |
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of Abeta1-40 in Rat serum, plasma and other biological fluids |
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![]() Rat beta-42(Amyloid Beta 1-42) ELISA Kit |
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STJ150196 | St John's Laboratory | 1 kit | 494.4 EUR |
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of Abeta1-42 in Rat serum, plasma and other biological fluids |
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![]() Human amyloid beta A4 protein ELISA Kit |
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1-CSB-E14352h | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human amyloid beta A4 protein in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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![]() Beta-Amyloid (1-11) |
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A1002-10 | ApexBio | 10 mg | 373.2 EUR |
Description: Beta-amyloid (1-11) (Abeta or A?) (C56H76N16O22) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein. |
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![]() Beta-Amyloid (1-11) |
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A1002-25 | ApexBio | 25 mg | 498 EUR |
Description: Beta-amyloid (1-11) (Abeta or A?) (C56H76N16O22) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein. |
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![]() Beta-Amyloid (1-11) |
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A1002-5 | ApexBio | 5 mg | 247.2 EUR |
Description: Beta-amyloid (1-11) (Abeta or A?) (C56H76N16O22) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein. |
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![]() beta-Amyloid (1-11) |
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5-00416 | CHI Scientific | 4 x 5mg | Ask for price |
![]() beta-Amyloid (1-15) |
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5-00418 | CHI Scientific | 4 x 5mg | Ask for price |
![]() beta- Amyloid (1-16) |
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5-00419 | CHI Scientific | 4 x 1mg | Ask for price |
![]() beta-Amyloid (1-28) |
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5-00421 | CHI Scientific | 4 x 1mg | Ask for price |
![]() beta- Amyloid (1-33) |
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5-00422 | CHI Scientific | 4 x 1mg | Ask for price |
![]() beta- Amyloid (1-34) |
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5-00423 | CHI Scientific | 4 x 1mg | Ask for price |
![]() beta- Amyloid (1-37) |
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5-00424 | CHI Scientific | 4 x 1mg | Ask for price |
![]() beta-Amyloid (1-39) |
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5-00426 | CHI Scientific | 4 x 1mg | Ask for price |
![]() beta-Amyloid (1-49) |
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5-00430 | CHI Scientific | 4 x 1mg | Ask for price |
![]() beta-Amyloid(40-1) |
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5-00456 | CHI Scientific | 4 x 1mg | Ask for price |
![]() Beta Amyloid 1-42 |
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AG138 | Unibiotest | 1 mg | 627.6 EUR |
![]() Beta Amyloid |
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MO20004 | Neuromics | 100 ug | 295.2 EUR |
![]() Beta Amyloid |
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MO22142 | Neuromics | 100 ul | 522 EUR |
![]() Human Interleukin-1 beta (IL-1 beta) AssayMax ELISA Kit |
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EI2200-1 | AssayPro | 96 Well Plate | 572.4 EUR |
![]() Mouse Interleukin-1 beta (IL-1 beta) AssayMax ELISA Kit |
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EMI2200-1 | AssayPro | 96 Well Plate | 572.4 EUR |
![]() Mouse Beta- defensin 38, Defb38 ELISA KIT |
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ELI-31016m | Lifescience Market | 96 Tests | 1038 EUR |
![]() TB (Mycobacterium Tuberculosis Antibody IgG) ELISA test |
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38 | Biobase | 96T/Box | Ask for price |
Description: ELISA based test for quantitative detection of TB (Mycobacterium Tuberculosis Antibody IgG) |
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![]() Human amyloid beta peptide 1-42, Aβ1-42 ELISA Kit |
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1-CSB-E10684h | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human amyloid beta peptide 1-42, Aβ1-42 in samples from serum, plasma, tissue homogenates, cerebrospinalfluid(CSF). Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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![]() Rat amyloid beta peptide 1-42, Aβ1-42 ELISA Kit |
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1-CSB-E10786r | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Rat amyloid beta peptide 1-42, Aβ1-42 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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![]() Mouse amyloid beta peptide 1-42, Aβ1-42 ELISA Kit |
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1-CSB-E10787m | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Mouse amyloid beta peptide 1-42, Aβ1-42 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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![]() Human amyloid beta peptide 1-40, Aβ1-40 ELISA Kit |
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1-CSB-E08299h | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human amyloid beta peptide 1-40, Aβ1-40 in samples from serum, tissue homogenates, cerebrospinalfluid(CSF). Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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![]() Mouse amyloid beta peptide 1-40, Aβ1-40 ELISA Kit |
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1-CSB-E08300m | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Mouse amyloid beta peptide 1-40, Aβ1-40 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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![]() Rat amyloid beta peptide 1-40, Aβ1-40 ELISA Kit |
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1-CSB-E08302r | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Rat amyloid beta peptide 1-40, Aβ1-40 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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![]() Monkey amyloid beta peptide 1-42, Aβ1-42 ELISA Kit |
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1-CSB-E14398Mk | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Monkey amyloid beta peptide 1-42, Aβ1-42 in samples from serum, plasma. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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![]() Mouse beta-40(Amyloid Beta Peptide 1-40)ELISA Kit |
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STJ150003 | St John's Laboratory | 1 kit | 494.4 EUR |
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of Abeta1-40 in Mouse serum, plasma and other biological fluids |
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![]() Human beta-40(Amyloid Beta Peptide 1-40) ELISA Kit |
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STJ150127 | St John's Laboratory | 1 kit | 494.4 EUR |
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of Abeta1-40 in human serum, plasma and other biological fluids |
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![]() Human beta-42(Amyloid Beta Peptide 1-42) ELISA Kit |
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STJ150128 | St John's Laboratory | 1 kit | 494.4 EUR |
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of Abeta1-42 in human serum, plasma and other biological fluids |
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![]() Streptavidin Mag Sepharose(R); Cytiva; 28-9857-38; pack of 2 x 1 mL |
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GE28-9857-38 | Scientific Laboratory Supplies | PK2 | 196.08 EUR |
![]() Rabbit amyloid beta peptide 1-40 ELISA kit |
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E04A0910-192T | BlueGene | 192 tests | 1524 EUR |
Description: A competitive ELISA for quantitative measurement of Rabbit amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Rabbit amyloid beta peptide 1-40 ELISA kit |
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E04A0910-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Description: A competitive ELISA for quantitative measurement of Rabbit amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Rabbit amyloid beta peptide 1-40 ELISA kit |
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E04A0910-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Description: A competitive ELISA for quantitative measurement of Rabbit amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Rat amyloid beta peptide 1-40 ELISA kit |
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E02A0910-192T | BlueGene | 192 tests | 1524 EUR |
Description: A competitive ELISA for quantitative measurement of Rat amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Rat amyloid beta peptide 1-40 ELISA kit |
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E02A0910-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Description: A competitive ELISA for quantitative measurement of Rat amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Rat amyloid beta peptide 1-40 ELISA kit |
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E02A0910-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Description: A competitive ELISA for quantitative measurement of Rat amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Monkey amyloid beta peptide 1-40 ELISA kit |
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E09A0910-192T | BlueGene | 192 tests | 1524 EUR |
Description: A competitive ELISA for quantitative measurement of Monkey amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Monkey amyloid beta peptide 1-40 ELISA kit |
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E09A0910-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Description: A competitive ELISA for quantitative measurement of Monkey amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Monkey amyloid beta peptide 1-40 ELISA kit |
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E09A0910-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Description: A competitive ELISA for quantitative measurement of Monkey amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Goat amyloid beta peptide 1-40 ELISA kit |
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E06A0910-192T | BlueGene | 192 tests | 1524 EUR |
Description: A competitive ELISA for quantitative measurement of Goat amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Goat amyloid beta peptide 1-40 ELISA kit |
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E06A0910-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Description: A competitive ELISA for quantitative measurement of Goat amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Goat amyloid beta peptide 1-40 ELISA kit |
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E06A0910-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Description: A competitive ELISA for quantitative measurement of Goat amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Dog amyloid beta peptide 1-40 ELISA kit |
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E08A0910-192T | BlueGene | 192 tests | 1524 EUR |
Description: A competitive ELISA for quantitative measurement of Canine amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Dog amyloid beta peptide 1-40 ELISA kit |
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E08A0910-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Description: A competitive ELISA for quantitative measurement of Canine amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Dog amyloid beta peptide 1-40 ELISA kit |
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E08A0910-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Description: A competitive ELISA for quantitative measurement of Canine amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Mouse amyloid beta peptide 1-40 ELISA kit |
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E03A0910-192T | BlueGene | 192 tests | 1524 EUR |
Description: A competitive ELISA for quantitative measurement of Mouse amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Mouse amyloid beta peptide 1-40 ELISA kit |
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E03A0910-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Description: A competitive ELISA for quantitative measurement of Mouse amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Mouse amyloid beta peptide 1-40 ELISA kit |
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E03A0910-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Description: A competitive ELISA for quantitative measurement of Mouse amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Human amyloid beta peptide 1-40 ELISA kit |
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E01A0910-192T | BlueGene | 192 tests | 1524 EUR |
Description: A competitive ELISA for quantitative measurement of Human amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Human amyloid beta peptide 1-40 ELISA kit |
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E01A0910-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Description: A competitive ELISA for quantitative measurement of Human amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Human amyloid beta peptide 1-40 ELISA kit |
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E01A0910-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Description: A competitive ELISA for quantitative measurement of Human amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Pig amyloid beta peptide 1-40 ELISA kit |
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E07A0910-192T | BlueGene | 192 tests | 1524 EUR |
Description: A competitive ELISA for quantitative measurement of Porcine amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Pig amyloid beta peptide 1-40 ELISA kit |
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E07A0910-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Description: A competitive ELISA for quantitative measurement of Porcine amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Pig amyloid beta peptide 1-40 ELISA kit |
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E07A0910-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Description: A competitive ELISA for quantitative measurement of Porcine amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Equine amyloid beta peptide 1- 40 ELISA Kit |
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ELA-E0864ELA-Eq | Lifescience Market | 96 Tests | 1113.6 EUR |
![]() Human amyloid beta peptide 1- 40 ELISA Kit |
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ELA-E0864h | Lifescience Market | 96 Tests | 988.8 EUR |
![]() Monkey amyloid beta peptide 1- 40 ELISA Kit |
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ELA-E0864Mo | Lifescience Market | 96 Tests | 1113.6 EUR |
![]() Rabbit amyloid beta peptide 1- 40 ELISA Kit |
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ELA-E0864Rb | Lifescience Market | 96 Tests | 1113.6 EUR |
![]() Amyloid ?-Protein (1-15) |
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A1003-1 | ApexBio | 1 mg | 135.6 EUR |
Description: Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid. |
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![]() Amyloid Beta 42 (Human) ELISA Kit |
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E4288-100 | Biovision | 966 EUR | |
![]() Amyloid P Component (33-38) amide |
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5-00671 | CHI Scientific | 4 x 5mg | Ask for price |
![]() Amyloid P Component (27-38) amide |
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H-2942.0001 | Bachem | 1.0mg | 135.6 EUR |
Description: Sum Formula: C68H107N19O17S; CAS# [180387-75-1] net |
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![]() Amyloid P Component (27-38) amide |
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H-2942.0005 | Bachem | 5.0mg | 297.6 EUR |
Description: Sum Formula: C68H107N19O17S; CAS# [180387-75-1] net |
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![]() Amyloid P Component (33-38) amide |
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H-2946.0005 | Bachem | 5.0mg | 348 EUR |
Description: Sum Formula: C37H56N10O7S; CAS# [180387-76-2] net |
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![]() Amyloid P Component (33-38) amide |
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H-2946.0025 | Bachem | 25.0mg | 1280.4 EUR |
Description: Sum Formula: C37H56N10O7S; CAS# [180387-76-2] net |
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![]() PACAP 6-38 |
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B7325-1 | ApexBio | 1 mg | 348 EUR |
![]() Mouse Amyloid beta A4 protein(APP) ELISA kit |
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1-CSB-EL001950MO | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Mouse Amyloid beta A4 protein(APP) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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![]() Rat Amyloid beta A4 protein(APP) ELISA kit |
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1-CSB-EL001950RA | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Rat Amyloid beta A4 protein(APP) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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![]() Human TGF-beta-1 AssayMax ELISA Kit |
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ET3102-1 | AssayPro | 96 Well Plate | 572.4 EUR |
![]() [Gln11] -beta- Amyloid (1 - 16) |
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5-00185 | CHI Scientific | 4 x 5mg | Ask for price |
![]() [Gln11] -beta- Amyloid (1 - 28) |
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5-00186 | CHI Scientific | 4 x 1mg | Ask for price |
![]() [Gln11] -beta- Amyloid (1 - 40) |
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5-00187 | CHI Scientific | 4 x 1mg | Ask for price |
![]() [Gln22] -beta- Amyloid (1 - 40) |
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5-00190 | CHI Scientific | 4 x 1mg | Ask for price |
![]() [Gly22] -beta- Amyloid (1 - 40) |
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5-00201 | CHI Scientific | 4 x 1mg | Ask for price |
![]() [Val35] -beta - Amyloid (1 - 42) |
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5-00369 | CHI Scientific | 4 x 1mg | Ask for price |
![]() beta-Amyloid (1-40), rat |
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5-00427 | CHI Scientific | 4 x 1mg | Ask for price |
![]() beta-Amyloid (1-42), human |
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5-00429 | CHI Scientific | 4 x 1mg | Ask for price |
![]() Amyloid beta-Protein (1-43) |
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5-00662 | CHI Scientific | 4 x 1mg | Ask for price |
![]() Amyloid beta-Protein (42-1) |
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5-00667 | CHI Scientific | 4 x 1mg | Ask for price |
![]() Cys-beta- Amyloid (1 - 40) |
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5-01014 | CHI Scientific | 4 x 1mg | Ask for price |
![]() Amyloid beta 1-42 Protein |
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abx060277-100ug | Abbexa | 100 ug | 910.8 EUR |
![]() Amyloid beta (1-40) Antibody |
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abx020617-100ug | Abbexa | 100 ug | 1178.4 EUR |
![]() Amyloid beta (1-42) Antibody |
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abx020619-100ug | Abbexa | 100 ug | 1178.4 EUR |
![]() beta Amyloid (1-14) Peptide |
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20-abx265397 | Abbexa |
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![]() beta Amyloid (1-11) Peptide |
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20-abx266241 | Abbexa |
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![]() beta Amyloid (1-15) Peptide |
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20-abx266490 | Abbexa |
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![]() Anti-beta Amyloid 1-42 |
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AT138 | Unibiotest | 1mg | 1336.8 EUR |
![]() beta Amyloid 1-42 Antibody |
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AF0019 | Affbiotech | 100ul | 420 EUR |
![]() Amyloid ?-Peptide (1-42) (human) |
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B6057-.1 | ApexBio | 100 ug | 331.2 EUR |
![]() FL-411 |
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HY-111102 | MedChemExpress | 25mg | 1575.6 EUR |
![]() Amyloid Beta Peptide 1-42 (Ab1-42) ELISA Kit |
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20-abx258778 | Abbexa |
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![]() Guinea pig amyloid beta peptide 1-40 ELISA kit |
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E05A0910-192T | BlueGene | 192 tests | 1524 EUR |
Description: A competitive ELISA for quantitative measurement of Guinea pig amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Guinea pig amyloid beta peptide 1-40 ELISA kit |
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E05A0910-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Description: A competitive ELISA for quantitative measurement of Guinea pig amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Guinea pig amyloid beta peptide 1-40 ELISA kit |
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E05A0910-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Description: A competitive ELISA for quantitative measurement of Guinea pig amyloid beta peptide 1-40 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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![]() Beta-APP42 ELISA Kit| Mouse Beta-amyloid protein 42 ELISA Kit |
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EF013161 | Lifescience Market | 96 Tests | 826.8 EUR |
![]() Mouse Beta-APP42/ Beta-amyloid protein 42 ELISA Kit |
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E0175Mo | Sunlong | 1 Kit | 685.2 EUR |
![]() Human Beta-APP42/ Beta-amyloid protein 42 ELISA Kit |
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E0270Hu | Sunlong | 1 Kit | 685.2 EUR |
![]() Mouse Beta- amyloid protein 42, Beta- APP42 ELISA KIT |
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ELI-03782m | Lifescience Market | 96 Tests | 1038 EUR |
![]() Human Beta- amyloid protein 42, Beta- APP42 ELISA KIT |
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ELI-03783h | Lifescience Market | 96 Tests | 988.8 EUR |
![]() beta Amyloid antibody |
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70R-10624 | Fitzgerald | 1 ml | 831.6 EUR |
Description: Affinity purified Chicken polyclonal beta Amyloid antibody |
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![]() beta Amyloid antibody |
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70R-12571 | Fitzgerald | 100 ul | 548.4 EUR |
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody |
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![]() Beta Amyloid antibody |
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70R-51450 | Fitzgerald | 100 ul | 344.4 EUR |
Description: Purified Polyclonal Beta Amyloid antibody |
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![]() beta Amyloid protein |
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30R-3244 | Fitzgerald | 50 ug | 308.4 EUR |
Description: Purified recombinant beta Amyloid protein |
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![]() beta Amyloid Antibody |
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35506-100ul | SAB | 100ul | 468 EUR |
![]() beta Amyloid antibody |
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20R-AR011 | Fitzgerald | 250 ul | 457.2 EUR |
Description: Rabbit polyclonal beta Amyloid antibody |
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![]() beta Amyloid antibody |
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10R-7917 | Fitzgerald | 100 ug | 386.4 EUR |
Description: Mouse monoclonal beta Amyloid antibody |
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![]() beta Amyloid antibody |
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10R-A124a | Fitzgerald | 50 ug | 1213.2 EUR |
Description: Mouse monoclonal beta Amyloid antibody |
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![]() beta-Amyloid antibody |
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22965-100ul | SAB | 100ul | 468 EUR |
![]() beta Amyloid antibody |
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70R-AR020 | Fitzgerald | 100 ug | 360 EUR |
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody |
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![]() beta Amyloid antibody |
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70R-BR019 | Fitzgerald | 100 ug | 360 EUR |
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody |
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![]() Amyloid beta Antibody |
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F49577-0.4ML | NSJ Bioreagents | 0.4 ml | 379 EUR |
![]() PACAP (1-38), Human, Ovine, Rat |
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SP-52290-1 | Alpha Diagnostics | 0.5 mg | 421.2 EUR |
![]() Human amyloid beta A4 protein ELISA Kit |
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CSB-E14352h-24T | Cusabio | 1 plate of 24 wells | 198 EUR |
Description: Quantitativesandwich ELISA kit for measuring Human amyloid beta A4 protein in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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![]() Rat Aβ40(Amyloid Beta 40) ELISA Kit |
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ER0754 | FN Test | 96T | 571.5 EUR |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 46.875pg/ml |
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![]() Rat Aβ42(Amyloid Beta 42) ELISA Kit |
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ER0755 | FN Test | 96T | 571.5 EUR |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 9.375pg/ml |
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![]() Human Aβ40(Amyloid Beta 40) ELISA Kit |
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EH2684 | FN Test | 96T | 628.92 EUR |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 4.688pg/ml |
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![]() Human Aβ42(Amyloid Beta 42) ELISA Kit |
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EH2685 | FN Test | 96T | 628.92 EUR |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 2.813pg/ml |
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![]() Mouse Aβ40(Amyloid Beta 40) ELISA Kit |
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EM0863 | FN Test | 96T | 571.5 EUR |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 46.875pg/ml |
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![]() Mouse Aβ42(Amyloid Beta 42) ELISA Kit |
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EM0864 | FN Test | 96T | 571.5 EUR |
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 2.344pg/ml |
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![]() Human Beta amyloid precursor protein ELISA Kit |
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ELA-E1020h | Lifescience Market | 96 Tests | 988.8 EUR |
![]() Tyr-Amyloid P Component (27-38) amide |
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5-02031 | CHI Scientific | 4 x 5mg | Ask for price |
![]() Amyloid P Component (33-38) amide Peptide |
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20-abx265867 | Abbexa |
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![]() Tyr-Amyloid P Component (27-38) amide |
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H-2944.0001 | Bachem | 1.0mg | 135.6 EUR |
Description: Sum Formula: C77H116N20O19S; CAS# [198268-71-2] net |
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![]() Tyr-Amyloid P Component (27-38) amide |
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H-2944.0005 | Bachem | 5.0mg | 298.8 EUR |
Description: Sum Formula: C77H116N20O19S; CAS# [198268-71-2] net |
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![]() Human Amyloid Precursor Protein (APP) AssayMax ELISA Kit |
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EA5801-1 | AssayPro | 96 Well Plate | 572.4 EUR |
![]() Human Serum Amyloid A (SAA) AssayMax ELISA Kit |
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EA8001-1 | AssayPro | 96 Well Plate | 500.4 EUR |
![]() Amyloid Stain Kit (Congo Red) |
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AMY-1 | ScyTek Laboratories | 1 kit(s) | 198 EUR |
![]() ELISA kit for Rat Amyloid beta (ABeta) Kit |
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KTE101129-48T | Abbkine | 48T | 424.8 EUR |
Description: Quantitative sandwich ELISA for measuring Rat Amyloid beta (ABeta) Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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![]() ELISA kit for Rat Amyloid beta (ABeta) Kit |
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KTE101129-5platesof96wells | Abbkine | 5 plates of 96 wells | 2702.4 EUR |
Description: Quantitative sandwich ELISA for measuring Rat Amyloid beta (ABeta) Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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![]() ELISA kit for Rat Amyloid beta (ABeta) Kit |
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KTE101129-96T | Abbkine | 96T | 686.4 EUR |
Description: Quantitative sandwich ELISA for measuring Rat Amyloid beta (ABeta) Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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![]() Human Interleukin 38(IL-38) ELISA Kit |
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QY-E05451 | Qayee Biotechnology | 96T | 433.2 EUR |
![]() Human amyloid beta peptide 1-40,A?1-40 ELISA Kit |
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201-12-1231 | SunredBio | 96 tests | 528 EUR |
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
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![]() Human amyloid beta peptide 1-42, Aβ1-42 ELISA Kit |
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CSB-E10684h-24T | Cusabio | 1 plate of 24 wells | 198 EUR |
Description: Quantitativesandwich ELISA kit for measuring Human amyloid beta peptide 1-42, Aβ1-42 in samples from serum, plasma, tissue homogenates, cerebrospinalfluid (CSF). A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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![]() Rat amyloid beta peptide 1-42, Aβ1-42 ELISA Kit |
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CSB-E10786r-24T | Cusabio | 1 plate of 24 wells | 198 EUR |
Description: Quantitativesandwich ELISA kit for measuring Rat amyloid beta peptide 1-42, Aβ1-42 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Together, computational outcomes corroborated experiments contributing with atomistic particulars to the information on this biologically related trimolecular system. Additionally, a high-throughput rigorous evaluation of the free power calculations information was carried out to critically consider the utilized computational methodologies.
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