Description: The choroid plexus epithelial cells (CPEpiC) are the structural basis, form a selective barrier between the nervous system and the blood, and secrete cerebrospinal fluid into the ventricles of the brain. CPEpiC express inward-rectifying anion channels which are thought to have an important role in the secretion of cerebrospinal fluid. CPEpiC synthesize and secrete many growth factors and other peptides that are of trophic benefit following injury to regions of the cerebroventricular system. For example, several growth factors are upregulated in choroid plexus after ischemic and traumatic insults to the central nervous system. The presence of numerous types of growth factor receptors in choroid plexus allows growth factor mediation of recovery processes by autocrine and paracrine mechanisms. CPEpiC culture has been widely used to evaluate their morphological and physiological properties, and its capacity to serve as an in vitro model to access the cellular mechanisms of organic cation transport across the cerebrospinal fluid-blood barrier.HCPEpiC from Gentaur Research Laboratories are isolated from human choroid plexus. HCPEpiC are cryopreserved after purification and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HCPEpiC are characterized by immunofluorescent method with antibodies to cytokeratin-18, -19 and vimentin. HCPEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HCPEpiC are guaranteed to further expand for 15 population doublings in the conditions specified by Gentaur Research Laboratories.

Description: The choroid plexus plays a wide range of roles in brain development, maturation, aging process, endocrine regulation, and pathogenesis of certain neurodegenerative diseases. The choroid plexuses consist of a single layer of epithelial cells enclosing a vascular core that together form the blood-cerebrospinal fluid barrier. The choroidal capillary is a single layer of endothelial cells interrupted by "pores" which exhibit a diaphragm between the lumen and the interstitial space. Study shows that choroid plexus endothelial cells express high Glut1 glucose transporter. The high glucose transport densities in choroids plexus endothelial cells is consistent with the suggestion that choroids epithelial and endothelial cells provide a metabolic work capability for maintaining ionic gradients and secretory functions across the blood-cerebrospinal fluid barriers.HCPEC from Gentaur Research Laboratories are isolated from human brain. HCPEC are cryopreserved after purification and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HCPEC are characterized by immunofluorescent method with antibodies to VWF/Factor VIII, CD31(PCAM) and by uptake of DiI-Ac-LDL. HBMEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HCPEC are guaranteed to further expand for 15 population doublings in the condition provided by Gentaur Research Laboratories.

Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.