Description: Available in various conjugation types.

Description: Available in various conjugation types.

Description: Rabbit polyclonal Breast Tumor Kinase antibody

Description: Rabbit polyclonal Breast Tumor Kinase antibody

Description: BRCA1, mapped to 17q21.3, is also known as BRCC1. This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). BRCA1 product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. In addition to it, BRCA1 may normally serve as a negative regulator of mammary epithelial cell growth and that this function is compromised in breast cancer either by direct mutation or by alterations in gene expression.

Description: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Description: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Description: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Description: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Description: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Description: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Description: BRCA1 (Breast cancer type 1 susceptibility protein) is a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Description: BRCA1 (Breast cancer type 1 susceptibility protein) is a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Description: BRCA1 (Breast cancer type 1 susceptibility protein) is a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Description: BRCA1 (Breast cancer type 1 susceptibility protein) is a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Description: BRCA1 (Breast cancer type 1 susceptibility protein) is a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Description: BRCA1 (Breast cancer type 1 susceptibility protein) is a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Description: BRCA1, mapped to 17q21.3, is also known as BRCC1. This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). BRCA1 product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. In addition to it, BRCA1 may normally serve as a negative regulator of mammary epithelial cell growth and that this function is compromised in breast cancer either by direct mutation or by alterations in gene expression.

Description: Rabbit polyclonal Breast Tumor Kinase antibody (Tyr447)

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1398),CF680 conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1398),CF680 conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1472),CF680 conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1472),CF680 conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1398),CF680R conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1398),CF680R conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1472),CF680R conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1472),CF680R conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1398),CF405M conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1398),CF405M conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1472),CF405M conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1472),CF405M conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1398),CF543 conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1398),CF543 conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1472),CF543 conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1472),CF543 conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1398),CF555 conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1398),CF555 conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1472),CF555 conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1472),CF555 conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1398),CF770 conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1398),CF770 conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1472),CF770 conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1472),CF770 conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1398),CF660R conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1398),CF660R conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1472),CF660R conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1472),CF660R conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1398),PerCP conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1472),PerCP conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1398),RPE conjugate, Concentration: 0.1mg/mL

Description: Primary antibody against BRCA1 (Breast Marker) (BRCA1/1472),RPE conjugate, Concentration: 0.1mg/mL