Description: Rat Calvariae Osteoblasts are dissociated from Sprague Dawley rat embryos. These cells offer an excellent model system for the study of osteoblastic growth and mineralization and can be used in research applications for bone disease, repair and formation.

Description: Rat Calvarial Osteoblasts (RCO) are isolated from the calvaria bone of neonatal Sprague-Dawley rats. RCO are cryopreserved at primary cultures and delivered frozen. RCO are guaranteed to further expand for 10 population doublings in the conditions provided by Gentaur.

Description: Bone is a dynamic tissue, being continuously remodeled by the coordinated actions of osteoclasts and osteoblast lineage. Osteoblasts, the bone-forming cells, are derived originally from pluripotent mesenchymal stem cells. They synthesize and secrete organic extracellular matrix, osteoid, which is composed primarily of type I collagen. Osteoid is calcified by osteoblasts and during this process the cells become encased in lacunae within the calcified material and become osteocytes. Osteoblasts express protease-activated receptor-1 and vescular endothelial cell growth factor. Studies show that Leukemia inhibitory factor can bind to the osteoblast cell surface and induce bone formation both in vitro and in vivo. The balance between osteoblast recruitment, proliferation, differentiation and apoptosis in sutures between cranial bones is essential for calvarial bone formation.HCO from Gentaur Research Laboratories are isolated from human calvariae. HCO are cryopreserved at primary cultures and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HCO are characterized by the cytochemically detection of AP and mineral deposition. HCO are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HCO are guaranteed for 15 population doublings at the conditions provided by Gentaur Research Laboratories.

Description: Mouse monoclonal Bone Marrow antibody

Description: Available in various conjugation types.

Description: Available in various conjugation types.

Description: Integrin-binding sialoprotein, also known as Bone sialoprotein and BSP, is a major structural protein of the bone matrix. Bone sialoprotein is a predicted 35KD acidic glycoprotein that undergoes extensive posttranslational modifications and is visualized by western blot at up to 70KD. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. The BSP gene is mapped to 4q22.1.